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首页> 美国卫生研究院文献>Saudi Pharmaceutical Journal : SPJ >Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac Ethocel and Eudragit RS for periodontal pocket delivery
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Doxycycline hyclate-loaded in situ forming gels composed from bleached shellac Ethocel and Eudragit RS for periodontal pocket delivery

机译：华西环素杂环载于原位成型凝胶由漂白的虫胶ethocel和Eudragit rs用于牙周袋送货

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摘要

Polymeric material plays an important role as a matrix former in the modulation of drug release of antimicrobial-loaded in situ forming gel (ISG) for efficient periodontitis treatment. This study was conducted to compare three polymers, namely bleached shellac (BS), Ethocel (EC) and Eudragit RS (ERS), as matrix formers of doxycycline hyclate (DH)-loaded solvent exchange-induced ISG. All prepared ISGs, except 25% EC ISG, exhibited the Newtonian flow behaviour. Transformation from solution into matrix-like was achieved rapidly within 5 min. Increasing the amount of these polymers extended the release of DH. DH-loaded EC and ERS ISG systems exhibited high antimicrobial activity, and all ISGs were effective in inhibiting the growth of Staphylococcus aureus, Escherichia coli, Streptococcus mutans, Porphyromonas gingivalis and Candida albicans. By comparison, the DH-loaded ERS ISG, through the solvent exchange mechanism, was found to be ease in injection with low viscosity and sustained the release with higher concentration, meanwhile, it also exhibited interesting in vitro degradability and antimicrobial activities. Therefore, the DH-loaded ERS ISG exhibited a potential use for localized periodontal drug delivery system for the treatment periodontitis.
机译：聚合物材料在调制原位成型凝胶（ISG）的抗微生物释放的药物释放中起矩阵前的重要作用以进行有效的牙周炎治疗。进行该研究以比较三种聚合物，即漂白的虫胶（BS），ethocel（EC）和Eudragit Rs（ERS），作为十二胞环杂环杂环（DH） - 加载的溶剂交换诱导的ISG的基质成型剂。除25％EC ISG外，所有制备的ISG都展示了牛顿流动行为。在5分钟内快速地从溶液转化为基质。增加这些聚合物的量延伸了DH的释放。 DH加载的EC和ISG系统表现出高抗菌活性，并且所有ISG都有效抑制金黄色葡萄球菌，大肠杆菌，链球菌，卟啉尼宫曲​​和念珠菌肽的生长。相比之下，通过溶剂交换机制的DH负载物ISG被发现易于注射，并且具有较高浓度的释放，同时，它还表现出有趣的体外可降解性和抗微生物活性。因此，DH加载的ERS ISG表现出用于治疗牙周炎的局部牙周药物输送系统的潜在用途。

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