• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>Polymers >Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels
【2h】

Biomimetic Mineralization of Tannic Acid-Supplemented HEMA/SBMA Nanocomposite Hydrogels

机译：单宁酸补充HEMA / SBMA纳米复合水凝胶的仿生矿化

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

This study developed a tannic acid (TA)-supplemented 2-hydroxyethyl methacrylate-co-sulfobetaine methacrylate (HEMA-co-SBMA) nanocomposite hydrogel with mineralization and antibacterial functions. Initially, hybrid hydrogels were synthesized by incorporating SBMA into the HEMA network and the influence of SBMA on the chemical structure, water content, mechanical properties, and antibacterial characteristics of the hybrid HEMA/SBMA hydrogels was examined. Then, nanoclay (Laponite XLG) was introduced into the hybrid HEMA/SBMA hydrogels and the effects evaluated of the nanoclay on the chemical structure, water content, and mechanical properties of these supplemented hydrogels. The 50/50 hybrid HEMA/SBMA hydrogel with 30 mg/mL nanoclay showed outstanding mechanical properties (3 MPa) and water content (60%) compared to pure polyHEMA hydrogels. TA then went on to be incorporated into these hybrid nanocomposite hydrogels and its effects investigated on biomimetic mineralization. Scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDX) showed that bone-like spheroidal precipitates with a Ca/P ratio of 1.67% were observed after 28 days within these mineralized hydrogels. These mineralized hydrogels demonstrated an almost 1.5-fold increase in compressive moduli compared to the hydrogels without mineralization. These multifunctional hydrogels display good mechanical and biomimetic properties and may have applications in bone regeneration therapies.
机译：该研究开发了一种单宁酸（TA） - 普通的2-羟乙基甲基丙烯酸酯 - 共聚磺酸甲酯（HEMA-CO-SBMA）纳米复合水凝胶，具有矿化和抗菌功能。最初，通过将SBMA掺入HEMA网络中来合成杂种水凝胶，并检查了SBMA对化学结构，含水含量，机械性能和抗菌特性的影响，检查了杂交HEMA / SBMA水凝胶。然后，将纳米粘土（Laponite XLG）引入杂交HEMA / SBMA水凝胶中，并在这些补充水凝胶的化学结构，水含量和机械性能下评价的纳米粘土评价的效果。与纯多液水凝胶相比，具有30mg / mL纳米粘土的50/50杂交血管烯/ SBMA水凝胶显示出优异的机械性能（3MPa）和水含量（60％）。然后继续掺入这些杂种纳米复合水凝胶中，并在仿生矿化中研究其效果。扫描电子显微镜（SEM）和能量分散X射线光谱（EDX）显示，在这些矿化水凝胶中28天后观察到具有1.67％的Ca / P比的骨状球析沉淀。这些矿化水凝胶表明，与无矿化的水凝胶相比，压缩模育的增加几乎为1.5倍。这些多功能水凝胶显示出良好的机械和仿生性能，可具有骨再生疗法的应用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号