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首页> 美国卫生研究院文献>Polymers >In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System
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In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System

机译：原位光聚合丙烯酰胺水凝胶涂层醋酸纤维素纳米纤维用于药物递送系统

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摘要

In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible.
机译：在这项研究中，我们开发了用型非甾体抗炎药（NSAID）（布洛芬，IB）的乙酸纤维素纳米纤维（CANF）开发出乙酸碱纳米纤维（CANF），并使用两个连续使用聚（丙烯酰胺）（Poly-AAM）水凝胶聚合物涂覆步骤：静电纺丝过程，然后用AAM光聚合。涂覆的和非涂覆的CANF制剂的特征在于几种微观和光谱技术，以评估它们的物理化学性质。对IB的动力学释放曲线的分析表明，由于多AAM水凝胶聚合物的存在或不存在，IB的动力学释放曲线显示出明显的差异。多AAM涂层促进药物恒定释放速率，而不是更常规的爆发释放。非涂覆的CANF分别显示出低累积的药物释放浓度（CA.35和83％，分别为5％和10％载荷）。相反，发现多AAM涂覆的CANF，促进药物（CA.8.8和99.8％分别为5％和10％载荷）的释放。最后，发现CANF是非常具有细胞势的。

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