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首页> 美国卫生研究院文献>Veterinary Research Forum >Protective effects of Citrullus lanatus seed ethanol extract on aluminum chloride-induced testosterone testicular and hematological changes in an experimental male rat model
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Protective effects of Citrullus lanatus seed ethanol extract on aluminum chloride-induced testosterone testicular and hematological changes in an experimental male rat model

机译：枸杞子乙醇提取物对实验性雄性大鼠模型氯化铝诱导睾酮睾丸和血液变化的保护作用

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The study was done to ascertain the protective potentials of ethanol seed extract of Citrullus lanatus on aluminum chloride-induced reproductive and hematological toxicities. Thirty mature male rats were used for the study. They were assigned into five groups (n = 6). Group 1 was treated daily with aluminum chloride (100 mg kg-1) per os for 8 weeks. Group 2 was treated with aluminum chloride (100 mg kg-1) and C. lanatus seed extract (CLSE) 200 mg kg-1 per os simultaneously for 8 weeks. Group 3 was served as a normal control and given distilled water as a placebo per os daily for 8 weeks. Group 4 was only treated with CLSE (200 mg kg-1) for eight weeks. Group 5 was only treated with aluminum chloride (100 mg kg-1) per os for 8 weeks and then treated with CLSE (200 mg kg-1) per os for another 4 weeks. Testosterone level, testicular weight, sperm motility, gonadal sperm, and extragonadal sperm reserves showed significant increases in group 2 compared to groups 1 and 5. Optimum histoarchitectural protection of the seminiferous tubules was observed in group 2, which did not differ from normal ones. For the hematological parameters, optimum protection was also observed in group 2 compared to other groups. From the results, ethanol seed extract of C. lanatus demonstrated protective potentials against aluminum's harmful effects on the male reproductive system and hematology in an experimental male rat model.
机译：该研究是为了确定柑橘类乙醇种子提取物对氯化铝诱导的繁殖和血液毒性乙醇种子提取物的保护势。三十种成熟的雄性大鼠用于研究。它们被分配为五组（n = 6）。每次用氯化铝（100mg KG-1）处理第1组8周。将第2组用氯化铝（100mg KG-1）和C.LANATS种子提取物（CLSE）同时用氯化铝（100mg kg-1）和C.LANATS籽提取物（CLSE）8周。第3组用作正常对照，并将蒸馏水作为每天每天的安慰剂8周。第4组仅在CCSE（200mg KG-1）治疗八周。第5组仅在每对氯化铝（100mg kg-1）处理8周，然后每次操作系统用Clse（200mg Kg-1）处理4周。睾酮水平，睾丸重量，精子运动，性能和多体形精子储备在第2组比较和5组中显示出显着的增加。在第2组中观察到半因素的最佳组织构造保护，其与正常情况不同。对于血液学参数，与其他组相比，2组在第2组中观察到最佳保护。从结果，C.Lanatus的乙醇种子提取物证明了在实验性雄性大鼠模型中对阳性对雄性生殖系统和血液学产生的保护潜力。

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