首页> 美国卫生研究院文献>EBioMedicine >Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

【2h】

Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

机译：精液暴露背景下抗HIV宽度中和抗体PGT121的保护效果

代理获取

本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。

页面导航

摘要
著录项
相似文献
相关主题

摘要

HIV-1 infections occur following viral exposure at anogenital mucosal surfaces in the presence of semen. Semen contains immunosuppressive and pro-inflammatory factors. Semen from HIV-1-infected donors contains anti-HIV-1 antibodies. We assessed if passively infused anti-HIV-1 neutralizing antibody conferred protection from rectal SHIVSF162P3 challenge at semen exposed mucosae.

机译：在精液存在下的缺氧粘膜表面下病毒暴露后发生HIV-1感染。精液含有免疫抑制和促炎因子。来自HIV-1感染捐赠者的精液含有抗HIV-1抗体。我们评估了被动进入的抗HIV-1中和抗体赋予了精液暴露粘膜的直肠SHIVSF162P3攻击。

著录项

期刊名称 EBioMedicine
作者
Matthew S. Parsons; Anne B. Kristensen; Kevin J. Selva; Wen Shi Lee; Thakshila Amarasena; Robyn Esterbauer; Adam K. Wheatley; Benjamin R. Bavinton; Anthony D. Kelleher; Andrew E. Grulich; Georges Khoury; Jennifer A. Juno; Stephen J. Kent;
展开▼
作者单位

展开▼
年(卷),期 2021(-1),-1
年度 2021
页码 -1
总页数 11
原文格式 PDF
正文语种
中图分类
关键词

机译：HIV-1;宽度中和抗体;精液;FC依赖功能;

相似文献

外文文献
中文文献
专利

1. The Effects of Somatic Hypermutation on Neutralization and Binding in the PGT121 Family of Broadly Neutralizing HIV Antibodies [J] . Alejandra Ramos, Alison Mahan, Arup K. Chakraborty, PLoS Pathogens . 2013,第11期

机译：体细胞高变对广泛中和的HIV抗体PGT121家族中和和结合的影响。
2. Selection of human anti-HIV broadly neutralizing antibodies occurs within the context of frozen 1F7-idiotypic repertoire. [J] . Parsons MS, Rouleau D, Routy JP, AIDS . 2011,第10期

机译：人类抗HIV广泛中和抗体的选择发生在冷冻的1F7型表型库中。
3. Griffithsin Retains Anti-HIV-1 Potency with Changes in gp120 Glycosylation and Complements Broadly Neutralizing Antibodies PGT121 and PGT126 [J] . Journal of neurosurgical sciences . 2020,第1期

机译：Griffithsin保留抗HIV-1效力，随着GP120糖基化的变化和互补抗体PGT121和PGT126的补充
4. CO-FORMULATION OF BROADLY NEUTRALIZING ANTIBODIES 3BNC117 AND PGT121: ANALYTICAL CHALLENGES DURING PRE-FORMULATION CHARACTERIZATION AND STORAGE STABILITY STUDIES [C] . Ashaben Patel, Vineet Gupta, John M. Hickey, Conference on vaccine technology VI . 2018

机译：共同中和抗体3BNC117和PGT121的共同配制：配制前表征和储存稳定性研究中的分析挑战
5. Broadly Neutralizing Antibodies and Broadly Neutralizing Sera: Insights into HIV-1 Vaccine Design [D] . Walker, Laura M. 2011

机译：广泛中和抗体和广泛中和血清：对HIV-1疫苗设计的见解
6. Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys [O] . Boris Julg, Devin Sok, Stephen D. Schmidt, 2017

机译：具有不完全中和活性的中和抗体对猿猴免疫缺陷病毒在恒河猴中的保护作用
7. The effects of somatic hypermutation on neutralization and binding in the PGT121 family of broadly neutralizing HIV antibodies. [O] . Devin Sok, Uri Laserson, Jonathan Laserson, 2013

机译：体细胞超突变对广泛中和HIV抗体pGT121家族中和和结合的影响。

Protective efficacy of the anti-HIV broadly neutralizing antibody PGT121 in the context of semen exposure

摘要

著录项

相似文献

相关主题

期刊订阅