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首页> 美国卫生研究院文献>International Journal of Environmental Research and Public Health >The Effect of Flow Rate on a Third-Generation Sub-Ohm Tank Electronic Nicotine Delivery System—Comparison of CORESTA Flow Rates to More Realistic Flow Rates
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The Effect of Flow Rate on a Third-Generation Sub-Ohm Tank Electronic Nicotine Delivery System—Comparison of CORESTA Flow Rates to More Realistic Flow Rates

机译：流速对第三代亚欧姆坦克电子尼古丁输送系统的影响 - Coresta流速比较到更现实的流速

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摘要

Many types of electronic cigarettes (ECs) are currently in use, but the default flow rate used to simulate puffing is centered on tobacco cigarette flow rates. CORESTA offers several methods and technical guides for evaluation of ECs but there are few puffing topography studies focusing on sub-ohm ECs; differences between real-world usage and that found in the literature appear large. This study focuses on how power and flow rate affect the nicotine yield of a sub-ohm EC. A puffing system (Puff3rd) has been designed and used to produce and collect EC aerosol. Nicotine yield was measured by GC–MS at three power levels and four flow rates. Data analysis was conducted in SAS using the MIXED procedure. Power, flow rate, and their interaction were all significant predictors of nicotine yield. Nicotine yield increased with both the vaping power and the puff flow rate with significant interaction of the two. Findings indicate that using the current CORESTA flow rate (1100 mL/min) to evaluate third-generation ECs underestimates nicotine yield and likely overestimates pyrolysis products. Real users are expected to have 2–3× the nicotine dose measured at 1100 mL/min, which could confound epidemiological studies seeking to link nicotine delivery to product satisfaction and acceptability.
机译：目前正在使用许多类型的电子烟（ECS），但用于模拟膨化的默认流量以烟草卷烟流量为中心。 Coresta提供了几种方法和技术指南，用于评估ECS，但很少有膨胀的地形研究，重点研究了Sub-Ohm ECS;现实世界使用与文学中发现的差异显得很大。本研究重点介绍了功率和流速如何影响亚欧姆EC的尼古丁产量。膨化系统（PUFF3RD）设计并用于生产和收集EC气溶胶。通过GC-MS在三个功率水平和四个流速下测量尼古丁产量。数据分析使用混合程序在SAS中进行。功率，流速及其相互作用是尼古丁产量的所有重要预测因子。尼古丁产量随着VAPING功率和PUFF流速而增加，具有两者的显着相互作用。结果表明，使用目前的Coresta流速（1100ml / min）来评估第三代ECS低估尼古丁产量并可能高估热解产物。预计真正的用户将在1100毫升/分钟内测量2-3倍，可能会滥用流行病学研究，寻求将尼古丁交付链接到产品满意度和可接受性。

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