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首页> 美国卫生研究院文献>Molecules >The Tannins from Sanguisorba officinalis L. (Rosaceae): A Systematic Study on the Metabolites of Rats Based on HPLC–LTQ–Orbitrap MS2 Analysis
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The Tannins from Sanguisorba officinalis L. (Rosaceae): A Systematic Study on the Metabolites of Rats Based on HPLC–LTQ–Orbitrap MS2 Analysis

机译：来自Sanguisorba Officinalis L的单宁（Rosaceae）：基于HPLC-LTQ-orbitrap MS2分析的大鼠代谢产物进行系统研究

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摘要

Sanguisorba tannins are the major active ingredients in Sanguisorba ofJicinalis L. (Rosaceae), one of the most popular herbal medicines in China, is widely prescribed for hemostasis. In this study, three kinds of tannins extract from Sanguisorba officinalis L. (Rosaceae), and the metabolites in vivo and in vitro were detected and identified by high-pressure liquid chromatography, coupled with linear ion trap orbitrap tandem mass spectrometry (HPLC–LTQ–Orbitrap). For in vivo assessment, the rats were administered at a single dose of 150 mg/kg, after which 12 metabolites were found in urine, 6 metabolites were found in feces, and 8 metabolites were found in bile, while metabolites were barely found in plasma and tissues. For in vitro assessment, 100 μM Sanguisorba tannins were incubated with rat liver microsomes, liver cytosol, and feces, after which nine metabolites were found in intestinal microbiota and five metabolites were found in liver microsomes and liver cytosol. Moreover, the metabolic pathways of Sanguisorba tannins were proposed, which shed light on their mechanism.
机译：地榆鞣质在地榆ofJicinalis L.（蔷薇科），在中国最流行的草药之一的主要活性成分，止血广泛的处方。在这项研究中三种单宁从地榆（蔷薇科）提取物，并检测和通过高压液相色谱法确定，再加上线性离子阱轨道阱串联质谱（HPLC-LTQ在体内和体外代谢物 - 轨道）。对于体内评价，将大鼠以150mg / kg的单次剂量，之后，在尿中发现12种代谢物给药，6种代谢物在粪便中发现，而在胆汁中发现8种代谢物，而代谢物在血浆中几乎没有发现和组织。对于体外评估，100个μM地榆鞣质，用大鼠肝微粒体，肝细胞质和粪便，之后在肠道菌群中发现有9种代谢物和肝脏微粒体和细胞质的肝脏被发现有代谢产物培养。此外，地榆单宁的代谢途径提出，其在它们的机制阐明。

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