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首页> 美国卫生研究院文献>Polymers >Proof-of-Concept of Detection of Counterfeit Medicine through Polymeric Materials Analysis of Plastics Packaging
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Proof-of-Concept of Detection of Counterfeit Medicine through Polymeric Materials Analysis of Plastics Packaging

机译：通过聚合物材料分析塑料包装的伪造药物检测概念概念

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The detection of counterfeit pharmaceuticals is always a major challenge, but the early detection of counterfeit medicine in a country will reduce the fatal risk among consumers. Technically, fast laboratory testing is vital to develop an effective surveillance and monitoring system of counterfeit medicines. This study proposed the combination of Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) and Differential Scanning Calorimetry (DSC) for the quick detection of counterfeit medicines, through the polymer analysis of blister packaging materials. A sample set containing three sets of original and counterfeit medicine was analyzed using ATR-FTIR and DSC, while the spectra from ATR-FTIR were employed as a fingerprint for the polymer characterization. Intending to analyze the polymeric material of each sample, DSC was set at a heating rate of 10 °C min−l and within a temperature range of 0–400 °C, with nitrogen as a purge gas at a flow rate of 20 mL min−1. The ATR-FTIR spectra revealed the chemical characteristics of the plastic packaging of fake and original medicines. Further analysis of the counterfeit medicine’s packaging with DSC exhibited a distinct difference from the original due to the composition of polymers in the packaging material used. Overall, this study confirmed that the rapid analysis of polymeric materials through ATR-FTIR and comparing DSC thermograms of the plastic in their packaging effectively distinguished counterfeit drug products.
机译：伪造药品的检测始终是一个重大挑战，但在一个国家的假冒药物早期发现会降低消费者之间的致命风险。从技术上讲，快速的实验室测试对于开发有效的伪造药物监测系统至关重要。该研究提出了通过泡罩包装材料的聚合物分析来快速检测衰减总反射傅里叶变换红外变换红外（ATR-FTIR）和差示扫描量热法（DSC）的组合。使用ATR-FTIR和DSC分析包含三组原始和假冒药物的样品，而ATR-FTIR的光谱用作聚合物表征的指纹。打算分析每个样品的聚合物材料，DSC以10℃min-L的加热速率和0-400℃的温度范围内设定，用氮气为吹扫气体，流速为20mL min -1。 ATR-FTIR光谱揭示了假和原药的塑料包装的化学特性。进一步分析假冒药物包装与DSC的包装从原件表现出不同的差异，由于所用包装材料中的包装材料中的聚合物的组成。总体而言，本研究证实，通过ATR-FTIR对聚合物材料的快速分析，并将塑料的DSC热法测定其包装中有效尊重假冒药品。

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