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首页> 美国卫生研究院文献>Vaccines >COVID-19 Vaccine mRNABNT162b2 Elicits Human Antibody Response in Milk of Breastfeeding Women
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COVID-19 Vaccine mRNABNT162b2 Elicits Human Antibody Response in Milk of Breastfeeding Women

机译：Covid-19疫苗MRNABNT162B2在母乳喂养女性牛奶中引发人类抗体反应

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Objective: The objective of this research is to demonstrate the release of SARS-CoV-2 Spike (S) antibodies in human milk samples obtained by patients who have been vaccinated with mRNABNT162b2 vaccine. Methods: Milk and serum samples were collected in 10 volunteers 20 days after the first dose and 7 seven days after the second dose of the mRNABNT162b2 vaccine. Anti-SARS-CoV-2 S antibodies were measured by the Elecsys® Anti-SARS-CoV-2 S ECLIA assay (Roche Diagnostics AG, Rotkreuz, Switzerland), a quantitative electrochemiluminescence immunometric method. Results: At first sample, anti-SARS-CoV-2 S antibodies were detected in all serum samples (103.9 ± 54.9 U/mL) and only in two (40%) milk samples with a low concentration (1.2 ± 0.3 U/mL). At the second sample, collected 7 days after the second dose, anti-SARS-CoV-2 S antibodies were detected in all serum samples (3875.7 ± 3504.6 UI/mL) and in all milk samples (41.5 ± 47.5 UI/mL). No correlation was found between the level of serum and milk antibodies; the milk antibodies/serum antibodies ratio was on average 2% (range: 0.2–8.4%). Conclusion: We demonstrated a release of anti-SARS-CoV-2 S antibodies in the breast milk of women vaccinated with mRNABNT162b2. Vaccinating breastfeeding women could be a strategy to protect their infants from COVID-19 infection.
机译：目的：本研究的目的是展示通过用MRNABNT162B2疫苗接种疫苗的患者获得的人牛奶样品中的SARS-COV-2穗抗体的释放。方法：在MRNABNT162B2疫苗的第一次剂量后20天，在第一次剂量后20天收集牛奶和血清样品。通过Elecsys®抗SARS-COV-2 S Eclia测定（Roche Diagnostics Ag，Rotkreuz，瑞士），测量抗SARS-COV-2 S抗体，是一种定量电化学发光免疫测定方法。结果：在第一次样品中，在所有血清样品（103.9±54.9u / ml）中检测到抗SARS-COV-2 S抗体，仅在两（40％）浓度（1.2±0.3u / ml）中的两（40％）牛奶样品中）。在第二个剂量7天内收集的第二种样品，在所有血清样品中检测到抗SARS-COV-2S抗体（3875.7±3504.6 UI / mL）和所有牛奶样品（41.5±47.5 UI / ml）。在血清和乳抗体水平之间没有发现相关性;乳抗体/血清抗体比平均为2％（范围：0.2-8.4％）。结论：我们展示了用MRNABNT162B2疫苗的女性母乳中释放抗SARS-COV-2 S抗体。接种母乳喂养的女性可能是保护婴儿免受Covid-19感染的策略。

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