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首页> 美国卫生研究院文献>Viruses >Multiple Human Papilloma Virus (HPV) Infections Are Associated with HSIL and Persistent HPV Infection Status in Korean Patients
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Multiple Human Papilloma Virus (HPV) Infections Are Associated with HSIL and Persistent HPV Infection Status in Korean Patients

机译：多种人乳头瘤病毒（HPV）感染与韩国患者的HSIL和持久的HPV感染状况有关

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摘要

Infections with multiple human papilloma virus (HPV) types have been reported, but their role in cervical carcinogenesis has not been fully elucidated. In this study, 236 cases with multiple HPV infection were examined and compared to 180 cases with single HPV infection. HPV genotyping was performed with cervico-vaginal swab specimens using multiplex (real-time) polymerase chain reaction (PCR). In multiple HPV infection, the most prevalent HPV genotype was HPV 53, followed by HPV 16, 58, 52, and 68. HPV 33, 35, 39, 51, 52, 53, 58, and 68 were high-risk-HPV (HR-HPV) genotypes that were more frequently detected in multiple HPV infection compared to that in single HPV infection. The association between multiple HPV infection and high-grade SIL (HSIL) was significantly stronger compared to that of single HPV infection and HSIL (p = 0.002). Patients with multiple HPV infection displayed persistent and longer duration of the HPV infection compared to patients with single HPV infection. Multiple HPV infections have distinct clinicopathologic characteristics. Since it is associated with persistent HPV infection, HSIL, and different HR-HPV strains in contrast to single HPV infection, the presence of multiple HPV infection should be reported; close follow up is warranted.
机译：已经报道了具有多种人乳头瘤病毒（HPV）类型的感染，但它们在宫颈癌中的作用尚未完全阐明。在这项研究中，检查了236例具有多种HPV感染的情况，并与单一HPV感染的180例进行了比较。使用多重（实时）聚合酶链反应（PCR）对宫颈阴道拭子样本进行HPV基因分型。在多种HPV感染中，最流行的HPV基因型是HPV 53，其次是HPV 16,58,52和68. HPV 33,35,39,51,52,53,58和68位是高风险-HPV（与单一HPV感染相比，在多种HPV感染中更频繁地检测的HR-HPV）基因型。与单一HPV感染和HSIL相比，多种HPV感染和高级SIL（HSIL）之间的关联显着越强（P = 0.002）。与单一HPV感染的患者相比，多种HPV感染的患者显示出持续和更长的HPV感染持续时间。多种HPV感染具有明显的临床病理特征。由于它与持续的HPV感染，HSIL和不同的HR-HPV菌株与单个HPV感染相比，因此应报告多种HPV感染的存在;紧密跟进是有保证的。

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