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首页> 美国卫生研究院文献>Journal of Clinical Biochemistry and Nutrition >Serum Concentrations of Trace Elements in Patients with Crohn’s Disease Receiving Enteral Nutrition
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Serum Concentrations of Trace Elements in Patients with Crohn’s Disease Receiving Enteral Nutrition

机译：接受肠内营养的克罗恩病患者血清中的微量元素浓度

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We investigated the trace element status in Crohn’s disease (CD) patients receiving enteral nutrition, and evaluated the effects of trace element-rich supplementation. Thirty-one patients with CD were enrolled in this study. All patients were placed on an enteral nutrition regimen with Elental® (Ajinomoto pharmaceutical. Ltd., Tokyo, Japan). Serum selenium, zinc and copper concentrations were determined by atomic absorption spectroscopy. Serum selenoprotein P levels were determined by an ELISA system. Average serum levels of albumin, selenium, zinc and copper were 4.1 ± 0.4 g/dl, 11.2 ± 2.8 µg/dl, 71.0 ± 14.8 µg/dl, and 112.0 ± 25.6 µg/dl, respectively. In 9 patients of 31 CD patients, serum albumin levels were lower than the lower limit of the normal range. Serum selenium, zinc and copper levels were lower than lower limits in 12 patients, 9 patients and 1 patient, respectively. Serum selenium levels significantly correlated with both serum selenoprotein P levels and glutathione peroxidase activity. Supplementation of selenium (100 µg/day) and zinc (10 mg/day) for 2 months significantly improved the trace element status in CD patients. In conclusion, serum selenium and zinc levels are lower in many CD patients on long-term enteral nutrition. In these patients, supplementation of selenium and zinc was effective in improving the trace element status.
机译：我们调查了接受肠内营养的克罗恩病（CD）患者中的微量元素状况，并评估了补充微量元素的效果。本研究招募了31名CD患者。所有患者均接受Elental®（味之素制药有限公司，日本东京）进行肠内营养治疗。血清硒，锌和铜的浓度通过原子吸收光谱法测定。通过ELISA系统测定血清硒蛋白P水平。白蛋白，硒，锌和铜的平均血清水平分别为4.1±0.4 g / dl，11.2±2.8 µg / dl，71.0±14.8 µg / dl和112.0±25.6 µg / dl。 31名CD患者中有9名患者的血清白蛋白水平低于正常范围的下限。血清硒，锌和铜水平分别低于12例，9例和1例的下限。血清硒水平与血清​​硒蛋白P水平和谷胱甘肽过氧化物酶活性均显着相关。补充硒（100 µg /天）和锌（10 mg /天）两个月可以显着改善CD患者的微量元素状况。总之，许多长期接受肠内营养的CD患者的血清硒和锌水平较低。在这些患者中，补充硒和锌可有效改善微量元素的状况。

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