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首页> 美国卫生研究院文献>International Wound Journal >The effects of intravenous lidocaine on wound pain and gastrointestinal function recovery after laparoscopic colorectal surgery
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The effects of intravenous lidocaine on wound pain and gastrointestinal function recovery after laparoscopic colorectal surgery

机译：静脉注射利用椰油对腹腔镜结直肠手术后伤口疼痛和胃肠功能恢复的影响

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To evaluate the efficacy of intravenous lidocaine in relieving postoperative pain and promoting rehabilitation in laparoscopic colorectal surgery, we conducted this meta‐analysis. The systematic search strategy was performed on PubMed, EMBASE, Chinese databases, and Cochrane Library before September 2019. As a result, 10 randomised clinical trials were included in this meta‐analysis (n = 527 patients). Intravenous lidocaine significantly reduced pain scores at 2, 4, 12, 24, and 48 hours on movement and 2, 4, and 12 hours on resting‐state and reduced opioid requirement in first 24 hours postoperatively (weighted mean difference [WMD] = −5.02 [−9.34, −0.70]; P = .02). It also decreased the first flatus time (WMD: −10.15 [−11.20, −9.10]; P < .00001), first defecation time (WMD: −10.27 [−17.62, −2.92]; P = .006), length of hospital stay (WMD: −1.05 [−1.89, −0.21]; P = .01), and reduced the incidence of postoperative nausea and vomiting (risk ratio: 0.53 [0.30, 0.93]; P = .03) when compared with control group. However, it had no effect on pain scores at 24 and 48 hours at rest, the normal dietary time, and the level of serum C‐reactive protein. In summary, perioperative intravenous lidocaine could alleviate acute pain, reduce postoperative analgesic requirements, and accelerate recovery of gastrointestinal function in patients undergoing laparoscopic colorectal surgery.
机译：为了评估在减轻术后疼痛和腹腔镜结直肠手术，推动善后静脉利多卡因的功效，我们进行了荟萃分析。 2019年是九月结果之前，考研，文摘，中国数据库和Cochrane图书馆进行系统的搜索策略，10随机临床试验纳入本荟萃分析（N = 527例）。静脉内利多卡因在2显著降低疼痛评分，4，12，24，和48小时的运动和2,4，和12小时静息态和在第一个24小时，术后（加权平均差异[WMD]减少阿片要求= - 5.02 [-9.34，-0.70; P = 0.02）。它也降低了肛门排气时间：（WMD：-10.15 [-11.20，-9.10; P <0.00001），第一排便时间（WMD：-10.27 [-17.62，-2.92; P = 0.006）的，长度当与对照组相比住院时间（WMD：-1.05 [-1.89，-0.21]; P = 0.01），并减少术后恶心和呕吐（P = 0.03 0.53 [0.30，0.93]风险比）的发病率团体。然而，它有在24和48小时静止在疼痛评分无影响，正常饮食时间，血清C反应蛋白的水平。总之，围手术期静脉注射利多卡因能缓解急性疼痛，减少术后镇痛药的需求，并加快在腹腔镜结直肠癌手术患者胃肠功能的恢复。

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