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首页> 美国卫生研究院文献>Oxidative Medicine and Cellular Longevity >Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications
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Analysis of Serum and Urinal Copper and Zinc in Chinese Northeast Population with the Prediabetes or Diabetes with and without Complications

机译：中国东北地区糖尿病前期或无并发症糖尿病人群血清和尿液中铜锌的分析

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摘要

This study investigated the association of copper and zinc levels in the serum or urine of patients living in northeast China, with either prediabetes or diabetes. From January 2010 to October 2011, patients with type 1 diabetes (T1D, n = 25), type 2 diabetes (T2D, n = 137), impaired fasting glucose (IFG, n = 12) or impaired glucose tolerance (IGT, n = 15), and age/gender matched controls (n = 50) were enrolled. In the T2D group, there were 24 patients with nephropathy, 34 with retinopathy, and 50 with peripheral neuropathy. Serum copper levels were significantly higher in IFG, IGT, and T2D groups. Serum zinc level was dramatically lower, and urinary zinc level was significantly higher in both T1D and T2D subjects compared with controls. The serum zinc/copper ratio was significantly lower in all the patients with IFG, ITG, T1D, and T2D. The serum copper level was positively associated with HbA1c in T2D subjects. Simvastatin treatment in T2D patients had no significant effect on serum and urinary copper and zinc. These results suggest the need for further studies of the potential impact of the imbalanced serum copper and zinc levels on metabolic syndrome, diabetes, and diabetic complications.
机译：这项研究调查了居住在中国东北地区的糖尿病或糖尿病患者的血清或尿液中铜和锌水平的相关性。从2010年1月至2011年10月，患有1型糖尿病（T1D，n = 25），2型糖尿病（T2D，n = 137），空腹血糖受损（IFG，n = 12）或葡萄糖耐量受损（IGT，n = 15），并加入年龄/性别匹配的对照（n = 50）。在T2D组中，有24例肾病患者，34例视网膜病患者和50例周围神经病患者。 IFG，IGT和T2D组的血清铜水平明显更高。与对照组相比，T1D和T2D受试者的血清锌水平显着降低，尿锌水平显着升高。在所有患有IFG，ITG，T1D和T2D的患者中，血清锌/铜比显着降低。在T2D受试者中，血清铜水平与HbA1c正相关。辛伐他汀在T2D患者中的治疗对血清及尿铜和锌无显着影响。这些结果表明需要进一步研究血清铜和锌水平不平衡对代谢综合征，糖尿病和糖尿病并发症的潜在影响。

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