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首页> 美国卫生研究院文献>Journal of Clinical Biochemistry and Nutrition >Acetic acid is an oxidative stressor in gastric cancer cells
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Acetic acid is an oxidative stressor in gastric cancer cells

机译：乙酸是胃癌细胞中的氧化应激源

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Acetic acid can cause cellular injury. We previously reported that acetic acid induces cancer cell-selective death in rat gastric cells. However, the mechanism is unclear. Generally, cancer cells are more sensitive to reactive oxygen species than normal cells. Accordingly, in this study, we investigated the involvement of oxidative stress in cancer cell-selective death by acetic acid using normal gastric mucosal cells and cancerous gastric mucosal cells. The cancer cell-selective death was induced at the concentration of 2–5 µM acetic acid. Cancerous gastric mucosal cells had increased expression of monocarboxylic transporter 1 and high uptake of acetic acid, compared to normal gastric mucosal cells. The exposure of cancerous gastric mucosal cells to acetic acid enhanced production of reactive oxygen species and expression of monocarboxylic transporter 1, and induced apoptosis. In contrast, acetic acid showed minor effects in normal gastric mucosal cells. These results indicate that acetic acid induced cancer cell-selective death in gastric cells through a mechanism involving oxidative stress.
机译：乙酸会引起细胞损伤。先前我们报道乙酸在大鼠胃细胞中诱导癌细胞选择性死亡。但是，机制尚不清楚。通常，癌细胞比正常细胞对活性氧种类更敏感。因此，在这项研究中，我们使用正常的胃粘膜细胞和癌性胃粘膜细胞，研究了氧化应激与乙酸引起的癌细胞选择性死亡的关系。在2–5 µM乙酸浓度下诱导癌细胞选择性死亡。与正常胃粘膜细胞相比，癌性胃粘膜细胞单羧酸转运蛋白1的表达增加，并且乙酸摄入量较高。癌性胃粘膜细胞暴露于乙酸可增强活性氧的产生和单羧酸转运蛋白1的表达，并诱导细胞凋亡。相反，乙酸在正常的胃粘膜细胞中显示出较小的作用。这些结果表明乙酸通过涉及氧化应激的机制诱导胃细胞中癌细胞的选择性死亡。

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