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首页> 美国卫生研究院文献>Journal of Clinical Biochemistry and Nutrition >Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial
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Effect of egualen sodium hydrate on small-intestinal mucosal damage induced by low-dose aspirin: a prospective randomized clinical trial

机译：水芹黄芪酸钠对小剂量阿司匹林引起的小肠粘膜损伤的影响：一项前瞻性随机临床试验

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摘要

Low-dose aspirin, which is widely used to reduce the risk of cardio- and cerebrovascular thrombosis, often induces gastroenteropathy by increasing the permeability of the mucosa. However, therapeutic strategies for patients with low-dose aspirin-induced small intestinal injury have not been determined. We evaluated the preventative effect of egualen sodium hydrate, a gastro-protective agent that suppresses indomethacin-induced small-intestinal damage in rats, against small-intestinal mucosal damage induced by low-dose aspirin in healthy adult male volunteers. Participants were randomly allocated to receive aspirin 100 mg/kg daily (control group, n = 10) or aspirin 100 mg/kg plus egualen sodium 30 mg daily (egualen sodium group, n = 10). Small intestinal mucosal injury was evaluated by capsule endoscopy two weeks after initiation of drug administration. Fecal analyses (occult blood test, immunochemical test, transferrin measurement and calprotectin measurement) were carried out before and after treatment. Egualen sodium significantly suppressed the total number of small intestinal injuries detected by capsule endoscopy and the positive ratio for the fecal occult blood test. Daily use of 30 mg of egualen sodium showed a preventative effect on low-dose aspirin-induced small intestinal injury. Since acid suppression therapy was reported to exacerbate NSAIDs-induced enteropathy via dysbiosis, egualen sodium may be useful for patients treated with low-dose aspirin.
机译：小剂量阿司匹林广泛用于降低心脑血管血栓形成的风险，通常通过增加粘膜的通透性来诱发肠胃病。然而，尚未确定低剂量阿司匹林诱导的小肠损伤患者的治疗策略。我们评估了水芹素钠（一种抑制胃消炎痛引起的大鼠小肠损伤的胃保护剂）对健康成年男性志愿者低剂量阿司匹林引起的小肠粘膜损伤的预防作用。参与者被随机分配接受每日100 mg / kg的阿司匹林（对照组，n = 10）或每天服用100 mg / kg的阿司匹林加30毫克的尤加仑钠（尤加仑钠，n = 10）。开始给药两周后，通过胶囊内窥镜评估小肠粘膜损伤。在治疗前后进行粪便分析（隐血试验，免疫化学试验，转铁蛋白测定和钙卫蛋白测定）。依加仑钠显着抑制了胶囊内窥镜检查发现的小肠损伤的总数以及粪便潜血试验的阳性率。每天服用30 mg的鹅膏草精钠对小剂量阿司匹林引起的小肠损伤具有预防作用。由于据报道，酸抑制疗法可通过营养不良加重NSAIDs引起的肠病，因此，例如乙草胺钠可能对低剂量阿司匹林治疗的患者有用。

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