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首页> 美国卫生研究院文献>Molecular Medicine >Multiparameter analysis of clastogenic factors pro-oxidant cytokines and inflammatory markers in HIV-1-infected patients with asymptomatic disease opportunistic infections and malignancies.
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Multiparameter analysis of clastogenic factors pro-oxidant cytokines and inflammatory markers in HIV-1-infected patients with asymptomatic disease opportunistic infections and malignancies.

机译：多参数分析无症状疾病机会性感染和恶性肿瘤的HIV-1感染患者中的致裂因子促氧化剂细胞因子和炎性标志物的多参数分析。

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HIV-1-infected patients are in chronic oxidative stress and clastogenic factors (CFs) are present in their plasma. CFs from patients with HIV are formed via superoxide anion radical and stimulate further superoxide production. The pathophysiolgic significance and the exact composition of the circulating clastogenic material in patients with HIV is unknown. Cytokines, such as tumor necrosis factor-alpha (TNF-alpha), are increased in the plasma of patients with HIV and TNF-alpha shows clastogenic activity in vitro. The aim of this clinical study was to compare levels of CF in HIV-1-positive patients with asymptomatic disease, opportunistic infections, and malignancies with those in HIV-1-negative control groups and to correlate CF activity with CD4+ T cell numbers, the cytokines (TNF-alpha, interleukin-2 [IL-2], IL-6), and the inflammatory markers (C-reactive protein [CRP], neopterin, granulocyte elastase). CFs were significantly increased in all HIV-1-positive patients and in HIV-1-negative patients with malignant tumors. HIV-1-positive patients with Kaposi's sarcoma showed the highest CF activity in their plasma (p < 0.08). CFs appear very early in HIV infection, and they correlate negatively with CD4+ T cells, which are an indicator of disease activity. The presence of CF in the plasma of HIV-infected patients is not a general response to a viral infection because these factors are not increased in HIV-1-negative patients with viral infection (zoster). CFs are not specific for the HIV-1 infection; they also occur in HIV-1-negative patients with malignant tumors. There was a tendency towards a positive correlation (p < 0.14) between CF and TNF-alpha but there was no positive correlation of CF with IL-2, IL-6, CRP, elastase, and neopterin levels. This indicates that TNF-alpha may be among the components of CF in HIV-1-infected patients. In addition, other unidentified components may contribute to the clastogenic activity of the plasma or the composition of CF may vary from patient to patient. Further clinical studies with larger sample populations are necessary to analyze the composition of CF in HIV-1-positive patients.
机译：感染HIV-1的患者处于慢性氧化应激状态，血浆中存在致裂因子（CFs）。来自HIV患者的CFs是通过超氧阴离子自由基形成的，并刺激进一步的超氧化物产生。 HIV病人的病理生理学意义和循环产生胶结物的确切成分尚不清楚。 HIV病人血浆中的细胞因子，例如肿瘤坏死因子-α（TNF-alpha）升高，而TNF-α在体外显示出致胶化活性。这项临床研究的目的是将无症状疾病，机会感染和恶性肿瘤的HIV-1阳性患者的CF水平与HIV-1阴性对照组的CF水平进行比较，并将CF活性与CD4 + T细胞数量相关联。细胞因子（TNF-α，白介素2 [IL-2]，IL-6）和炎症标志物（C反应蛋白[CRP]，新蝶呤，粒细胞弹性蛋白酶）。在所有HIV-1阳性患者和HIV-1阴性恶性肿瘤患者中，CFs均显着增加。患有卡波济肉瘤的HIV-1阳性患者的血浆中CF活性最高（p <0.08）。 CFs很早就出现在HIV感染中，并且与CD4 + T细胞呈负相关，而CD4 + T细胞是疾病活动的指标。 HIV感染患者血浆中CF的存在并不是对病毒感染的普遍反应，因为在HIV-1阴性病毒感染患者（带状疱疹）中这些因素并未增加。 CF并非专门针对HIV-1感染；它们也发生在HIV-1阴性的恶性肿瘤患者中。 CF与TNF-α之间存在正相关（p <0.14）的趋势，但CF与IL-2，IL-6，CRP，弹性蛋白酶和新蝶呤水平无正相关。这表明TNF-α可能是HIV-1感染患者的CF成分之一。另外，其他未确定的成分可能有助于血浆的致胶凝活性，或者CF的组成可能因患者而异。为了分析HIV-1阳性患者中CF的组成，有必要对大量样本进行进一步的临床研究。

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