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首页> 美国卫生研究院文献>Molecular Medicine >Restoring the Balance of the Autonomic Nervous System as an Innovative Approach to the Treatment of Rheumatoid Arthritis
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Restoring the Balance of the Autonomic Nervous System as an Innovative Approach to the Treatment of Rheumatoid Arthritis

机译：恢复自主神经系统的平衡作为治疗类风湿关节炎的创新方法

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The immunomodulatory effect of the autonomic nervous system has raised considerable interest over the last decades. Studying the influence on the immune system and the role in inflammation of the sympathetic as well as the parasympathetic nervous system not only will increase our understanding of the mechanism of disease, but also could lead to the identification of potential new therapeutic targets for chronic immune-mediated inflammatory diseases, such as rheumatoid arthritis (RA). An imbalanced autonomic nervous system, with a reduced parasympathetic and increased sympathetic tone, has been a consistent finding in RA patients. Studies in animal models of arthritis have shown that influencing the sympathetic (via α- and β-adrenergic receptors) and the parasympathetic (via the nicotinic acetylcholine receptor α7nAChR or by electrically stimulating the vagus nerve) nervous system can have a beneficial effect on inflammation markers and arthritis. The immunosuppressive effect of the parasympathetic nervous system appears less ambiguous than the immunomodulatory effect of the sympathetic nervous system, where activation can lead to increased or decreased inflammation depending on timing, doses and kind of adrenergic agent used. In this review we will discuss the current knowledge of the role of both the sympathetic (SNS) and parasympathetic nervous system (PNS) in inflammation with a special focus on the role in RA. In addition, potential antirheumatic strategies that could be developed by targeting these autonomic pathways are discussed.
机译：在过去的几十年中，自主神经系统的免疫调节作用引起了相当大的兴趣。研究对交感神经系统和副交感神经系统的免疫系统的影响及其在炎症中的作用，不仅可以增进我们对疾病机理的了解，而且还可以为慢性免疫疾病的潜在新治疗靶标的确定提供帮助。介导的炎症性疾病，例如类风湿关节炎（RA）。在RA患者中，一致的自主神经系统失调，副交感减少和交感增强是一直以来的发现。对关节炎动物模型的研究表明，影响交感神经（通过α-和β-肾上腺素能受体）和副交感神经（通过烟碱乙酰胆碱受体α7nAChR或通过电刺激迷走神经）可以对炎症标志物产生有益的影响。和关节炎。副交感神经系统的免疫抑制作用似乎不如交感神经系统的免疫调节作用那么模糊，在交感神经系统中，激活可能导致炎症增加或减少，具体取决于时间，剂量和所用肾上腺素能药物的种类。在这篇综述中，我们将讨论交感神经系统（SNS）和副交感神经系统（PNS）在炎症中的作用的当前知识，特别关注RA中的作用。此外，讨论了可以通过靶向这些自主途径开发的潜在抗风湿策略。

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