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首页> 美国卫生研究院文献>Journal of Bacteriology >Note: Escherichia coli Clone Sonnei (Shigella sonnei) Had a Chromosomal O-Antigen Gene Cluster Prior to Gaining Its Current Plasmid-Borne O-Antigen Genes
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Note: Escherichia coli Clone Sonnei (Shigella sonnei) Had a Chromosomal O-Antigen Gene Cluster Prior to Gaining Its Current Plasmid-Borne O-Antigen Genes

机译：注意：大肠杆菌克隆Sonnei（Shigella sonnei）在获得其当前的质粒-Borne O-抗原基因之前具有染色体O-抗原基因簇。

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O antigen is part of the lipopolysaccharide present in the outer membrane of gram-negative bacteria. The surface-exposed O antigen is subject to selection by the host immune system, which may account for the maintenance of many different O-antigen forms. Characteristically, all genes specific to O-antigen synthesis are clustered in a region close to the his and gnd genes on the chromosome of Escherichia coli and related species. Shigella sonnei, essentially a clone of E. coli (E. coli clone Sonnei), is an important human pathogen and is unusual in that its O-antigen gene cluster is located on a plasmid. Our results suggest that it once had a normal chromosomal O-antigen gene cluster which has been largely deleted. We suggest that the O antigen encoded by the plasmid-borne genes offered a selective advantage in adapting to a new environment and that the chromosomal O-antigen genes were eventually inactivated. We also identified, by PCR and sequencing, a potential ancestor of E. coli Sonnei among the 166 known E. coli serotype strains.
机译：O抗原是存在于革兰氏阴性细菌外膜中的脂多糖的一部分。暴露于表面的O抗原受到宿主免疫系统的选择，这可能解释了许多不同O抗原形式的维持。在特征上，所有对O抗原合成具有特异性的基因都聚集在大肠埃希氏菌及相关物种染色体上的his和gnd基因附近的区域。痢疾志贺氏菌本质上是大肠杆菌的一个克隆（大肠杆菌克隆Sonnei），是一种重要的人类病原体，而且不常见，因为其O抗原基因簇位于质粒上。我们的结果表明，它曾经具有正常的染色体O抗原基因簇，而该簇已被大量删除。我们建议由质粒传播的基因编码的O抗原在适应新环境中提供了选择性的优势，并且染色体O抗原基因最终被灭活了。通过PCR和测序，我们还鉴定了166种已知大肠杆菌血清型菌株中大肠杆菌Sonnei的潜在祖先。

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