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首页> 美国卫生研究院文献>Journal of Basic and Clinical Pharmacy >Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B
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Evaluation of the antihypertensive activity and alpha adrenergic receptor interaction of cleistanthins A and B

机译：评估抗磷脂A和B的降压活性和α肾上腺素受体相互作用

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Hypertension was induced in male Sprague Dawley rats with twice weekly administration of deoxycorticosterone acetate (DOCA) salt (20 mg/kg s.c) for 4 weeks. They were divided into eight groups of six animals each viz., hypertensive control, standard (prazosin 1 mg/kg), cleistanthin A 12.5, 25, 50 mg/kg and cleistanthin B 12.5, 25 mg/kg, and 50 mg/kg. One more group served as normal control. The hypertension was induced in 4 weeks, and the animals were given assigned treatment in 5th week. The alteration in blood pressure (BP) was recorded weekly using a rodent noninvasive blood pressure system. At the end of the experiment alpha-adrenergic receptor response of drugs like adrenaline, nor adrenaline, dopamine (doses 1 μg and 2 μg) was recorded invasively. Two-way repeated measures ANOVA followed by Bonferroni post-hoc test was used to analyze the data. The systolic BP and diastolic BP of test groups rose to a higher level after DOCA administration and fell to the normal range (P < 0.05) following the administration of cleistanthins A and B. There were no differences in the weekly heart rate among the groups. In the test group animals pretreated with prazosin and cleistanthins, adrenaline, noradrenaline and dopamine failed to raise the mean arterial pressure and the end-diastolic pressure from baseline (P > 0.05) cleistanthins A and B exert a significant antihypertensive effect through alpha-adrenergic receptor blockade similar to prazosin.
机译：雄性Sprague Dawley大鼠诱发高血压，每周两次给予醋酸脱氧皮质酮（DOCA）盐（20 mg / kg s.c），持续4周。将它们分为八组，每组六只动物，分别是高血压对照，标准品（哌唑嗪1 mg / kg），cleistanthin A 12.5、25、50 mg / kg和cleistanthin B 12.5、25 mg / kg和50 mg / kg。 。另外一组作为正常对照。在4周内诱发高血压，并在第5sup 周给动物分配治疗。使用啮齿动物无创血压系统每周记录一次血压变化（BP）。在实验结束时，有创地记录了肾上腺素或肾上腺素等药物的多巴胺（剂量分别为1μg和2μg）的α-肾上腺素受体反应。使用双向重复测量方差分析，然后进行Bonferroni事后检验来分析数据。服用DOCA后，测试组的收缩压和舒张压升高至较高水平，并在施用抗胆红素A和B后降至正常范围（P <0.05）。各组之间的每周心率无差异。在测试组中，用哌唑嗪和抗胆碱药预处理的动物，肾上腺素，去甲肾上腺素和多巴胺未能使平均动脉压升高，并且舒张末期压力相对于基线水平（P> 0.05），抗胆碱药A和B通过α-肾上腺素能受体发挥显着的降压作用与哌唑嗪类似的封锁。

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