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首页> 美国卫生研究院文献>Journal of Assisted Reproduction and Genetics >The utility of serum leptin and follicular fluid leptin estradiol and progesterone levels during an in vitro fertilization cycle
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The utility of serum leptin and follicular fluid leptin estradiol and progesterone levels during an in vitro fertilization cycle

机译：体外受精周期中血清瘦素和卵泡液瘦素雌二醇和孕酮水平的应用

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Purpose: To prospectively evaluate serum and follicular fluid leptin, estradiol, and progesterone levels during in vitro fertilization.Methods: Prospective observational study measuring serum levels at six points during the IVF cycle and follicular fluid at the time of retrieval.Results: Serum leptin and estradiol levels both significantly increased for the individual patients during the IVF stimulation process. None of the leptin levels differed based on pregnancy outcome. BMI significantly correlated with all leptin levels. Follicular fluid estradiol correlated with serum estradiol only in pregnant patients (r = 0.97, p<0.01) and was unrelated in non-pregnant patients (r=−0.15, p=0.81).Conclusion: Serum and follicular leptin levels are highly correlated. Leptin levels increase during the IVF cycle and vary between patients based on maternal BMI, but do not correlate with other serum hormone levels or pregnancy outcome. Pregnancy outcome success was reflected in the relationship between follicular fluid and serum levels of estradiol, independent of leptin levels.
机译：目的：前瞻性评估体外受精过程中血清和卵泡液中的瘦素，雌二醇和孕酮的水平。方法：前瞻性观察性研究测量IVF周期中六个点的血清水平和取回时的卵泡液。结果：血清瘦素和在IVF刺激过程中，个别患者的雌二醇水平均显着增加。瘦素水平均未因妊娠结局而异。 BMI与所有瘦素水平显着相关。卵泡液雌二醇仅与妊娠患者的血清雌二醇相关（r correlat = 0.97，p <0.01），而与非妊娠患者则无相关性（r = -0.15，p = 0.81）。结论：血清和卵泡瘦素水平高度相关。瘦素水平在IVF周期中增加，并且因母体BMI而异，但与其他血清激素水平或妊娠结局无关。妊娠结局的成功反映在卵泡液和血清雌二醇水平之间的关系中，而与瘦素水平无关。

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