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首页> 美国卫生研究院文献>Journal of Assisted Reproduction and Genetics >Exosome-mediated communication in the ovarian follicle
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Exosome-mediated communication in the ovarian follicle

机译：卵泡中外体介导的交流

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摘要

Cells are able to produce and release different types of vesicles, such as microvesicles and exosomes, in the extracellular microenvironment. According to the scientific community, both microvesicles and exosomes are able to take on and transfer different macromolecules from and to other cells, and in this way, they can influence the recipient cell function. Among the different macromolecule cargos, the most studied are microRNAs. MicroRNAs are a large family of non-coding RNAs involved in the regulation of gene expression. They control every cellular process and their altered regulation is involved in human diseases. Their presence in mammalian follicular fluid has been recently demonstrated, and here, they are enclosed within microvesicles and exosomes or they can also be associated to protein complexes. The presence of microvesicles and exosomes carrying microRNAs in follicular fluid could represent an alternative mechanism of autocrine and paracrine communication inside the ovarian follicle. The outcomes from these studies could be important in basic reproductive research but could also be useful for clinical application. In fact, the characterization of extracellular vesicles in follicular fluid could improve reproductive disease diagnosis and provide biomarkers of oocyte quality in ART (Assisted Reproductive Treatment).
机译：细胞能够在细胞外微环境中产生和释放不同类型的囊泡，例如微囊泡和外泌体。根据科学界的看法，微泡和外泌体都能够吸收不同的大分子并将其转移到其他细胞中，并以此方式影响受体细胞的功能。在不同的大分子货物中，研究最多的是微RNA。 MicroRNA是涉及基因表达调控的一大类非编码RNA。它们控制着每个细胞过程，其改变的调节作用涉及人类疾病。最近已经证明了它们存在于哺乳动物卵泡液中，在这里，它们被包裹在微泡和外来体中，或者也可以与蛋白质复合物结合。卵泡液中带有microRNA的微泡和外泌体的存在可能代表卵巢滤泡内部自分泌和旁分泌通讯的另一种机制。这些研究的结果在基础生殖研究中可能很重要，但对临床应用也可能有用。实际上，表征卵泡液中细胞外囊泡可以改善生殖疾病的诊断，并在ART（辅助生殖治疗）中提供卵母细胞质量的生物标记。

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