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首页> 美国卫生研究院文献>Journal of Advanced Research >Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review
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Aromatase inhibitors induced autoimmune disorders in patients with breast cancer: A review

机译：芳香酶抑制剂诱导乳腺癌患者自身免疫性疾病的研究进展

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class="kwd-title">Keywords: Subacute cutaneous lupus erythematosus, Systemic lupus erythematosus, Rheumatoid arthritis, Arthralgias, Breast cancer, Aromatase inhibitors class="head no_bottom_margin" id="ab010title">AbstractSubacute cutaneous lupus erythematosus (SCLE) is characterized by particular cutaneous manifestations such as non-scaring plaques mainly in sunlight exposed parts of the body along with specific serum autoantibodies (i.e. antinuclear antibodies (ANA), Ro/SSa, La/SSb). It is considered either idiopathic or drug induced. The role of chemotherapeutic agents in causing SCLE has been investigated with the taxanes being the most common anticancer agents. However, recent data emerging point toward antiestrogen therapies as a causative factor not only for SCLE but also for a variety of autoimmune disorders. This is a report of a case of a 42 year old woman who developed clinical manifestations of SCLE after letrozole treatment in whom remission of the cutaneous manifestations was noticed upon discontinuation of the drug. In addition, an extensive review of the English literature has been performed regarding the association of antiestrogen therapy with autoimmune disorders. In conclusion, Oncologists should be aware of the potential development of autoimmune reactions in breast cancer patients treated with aromatase inhibitors.
机译：<！-fig ft0-> <！-fig @ position =“ anchor” mode =文章f4-> <！-fig mode =“ anchred” f5-> <！-fig / graphic | fig / alternatives / graphic mode =“ anchored” m1-> class =“ kwd-title”>关键字：亚急性皮肤性红斑狼疮，系统性红斑狼疮，类风湿性关节炎，关节痛，乳腺癌，芳香酶抑制剂摘要亚急性皮肤红斑狼疮（SCLE）的特征是特殊的皮肤表现，例如主要在阳光照射下的身体部位出现的无疤痕斑块以及特定的血清自身抗体（即抗核抗体（ANA），Ro / SSa，La / SSb）。它被认为是特发性的或药物诱导的。已经研究了化学治疗剂在引起SCLE中的作用，其中紫杉烷类是最常见的抗癌剂。但是，最近的数据表明，抗雌激素疗法不仅是SCLE的病因，而且是多种自身免疫性疾病的病因。这是一例42岁女性在来曲唑治疗后出现SCLE临床表现的报告，该药物停用后皮肤症状得以缓解。另外，关于抗雌激素疗法与自身免疫性疾病的关联，对英国文献进行了广泛的综述。总之，肿瘤学家应意识到用芳香化酶抑制剂治疗的乳腺癌患者自身免疫反应的潜在发展。

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