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首页> 美国卫生研究院文献>Journal of the American Association for Laboratory Animal Science : JAALAS >Operation of an Air Filtration Device Results in Morbidity and Mortality in Growing Chickens (Gallus gallus domesticus)
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Operation of an Air Filtration Device Results in Morbidity and Mortality in Growing Chickens (Gallus gallus domesticus)

机译：空气过滤装置的运行会导致成长中的鸡（鸡（Gallus gallus domesticus））的发病率和死亡率

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摘要

Environmental conditions may influence experimental outcomes in laboratory animals. In this study, we measured the effects of a vortex air-filtration device (AFD) on growth rate, morbidity, mortality, behavior, and gross pathology in P2a Leghorn chickens (Gallus gallus domesticus) raised from hatchlings to 6 wk of age. Growth rate was reduced in the group exposed to the operating AFD (‘AFD on’ group) compared with the 2 control groups (‘AFD off’ and ‘Historical’ groups). Similarly, 6-wk survival probability and body weight were decreased in the AFD-on group compared with controls. Splenic and cardiac weight indices were lower in the AFD-on and AFD-off groups compared with the Historical group. A progressive increase in the ambient sound level (Historical, 53.5 ± 1.7 dBA; AFD off, 63.6 ± 0.5 dBA; AFD on, 71.8 ± 0.8 dBA) was the only variable found to correlate with the physiologic differences observed across the 3 groups of growing chickens. These findings indicate that experimental outcomes with growing chickens are negatively affected by vortex air-filtration devices.
机译：环境条件可能会影响实验动物的实验结果。在这项研究中，我们测量了涡流空气过滤装置（AFD）对从孵化到6周龄的P2a来亨鸡（Gallus gallus domesticus）的生长速度，发病率，死亡率，行为和总体病理的影响。与2个对照组（“关闭AFD”和“历史记录”组）相比，正在运行AFD的组（“打开AFD”组）的增长率有所降低。同样，与对照组相比，AFD-on组的6周生存率和体重均降低。与历史组相比，AFD-on和AFD-off组的脾脏和心脏重量指数更低。唯一发现与周围3组生长中观察到的生理差异相关的变量是环境声级的逐渐增加（历史53.5±1.7 dBA; AFD关闭63.6±0.5 dBA; AFD打开71.8±0.8 dBA）鸡。这些发现表明，涡流空气过滤装置会对成鸡的实验结果产生负面影响。

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