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首页> 美国卫生研究院文献>Journal of the American Association for Laboratory Animal Science : JAALAS >Reference Intervals for Preprandial and Postprandial Serum Bile Acid in Adult Rhesus Macaques (Macaca mulatta)
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Reference Intervals for Preprandial and Postprandial Serum Bile Acid in Adult Rhesus Macaques (Macaca mulatta)

机译：成年猕猴（Macaca mulatta）餐前和餐后血清胆汁酸的参考间隔

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The purpose of this study was to determine the 12-h fasting preprandial and 2-h postprandial serum bile acid concentration (SBAC) reference intervals for healthy, adult rhesus macaques (Macaca mulatta). We hypothesized that the mean 2-h postprandial SBAC would be significantly higher than the mean preprandial SBAC. We included 40 (24 male, 16 female) macaques after confirming that their health records, physical examinations, CBC, serum chemistry panels, and urinalyses were all within normal limits. In addition, hepatitis A titers were determined, an ultrasound examination of the liver was performed, and two 16-gauge ultrasound guided percutaneous liver biopsies were collected and submitted for histopathology. Macaques were confirmed healthy according to hepatitis A screens and sonographic and histologic evaluation of hepatic tissue. Within 2 wk of the screening procedures, preprandial and postprandial SBACs were measured. Preprandial SBAC (mean ± 1 SD) was 11.1 ± 1.9 µmol/L and postprandial SBAC was 19.7 ± 8.0 µmol/L, which was significantly higher than the preprandial value. Sex and hepatitis titers did not significantly influence preprandial and postprandial SBAC. The current study indicates that the SBAC reference values for rhesus macaques are higher than those reported for humans and companion animals.
机译：这项研究的目的是确定健康的成年恒河猴（Macaca mulatta）的餐前12小时餐前和餐后2小时血清胆汁酸浓度（SBAC）参考间隔。我们假设平均餐后2小时SBAC将明显高于平均餐前SBAC。在确认它们的健康记录，体格检查，CBC，血清化学成分和尿液检查均在正常范围内后，我们包括了40只（24雄性，16雌性）猕猴。此外，确定了甲型肝炎的滴度，对肝脏进行了超声检查，并收集了两个16线超声引导的经皮肝穿刺活检，并进行了组织病理学检查。根据甲型肝炎筛查以及肝组织的超声和组织学评估，猕猴被确认为健康。在筛查程序的2周内，对餐前和餐后SBAC进行了测量。餐前SBAC（平均值±1 SD）为11.1±1.9 µmol / L，餐后SBAC为19.7±8.0 µmol / L，明显高于餐前值。性别和肝炎滴度没有显着影响餐前和餐后SBAC。当前的研究表明，恒河猴的SBAC参考值高于人类和伴侣动物的参考值。

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