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首页> 美国卫生研究院文献>Journal of the American Association for Laboratory Animal Science : JAALAS >Efficacy of Fenbendazole Formulated in a Commercial Primate Diet for Treating Specific Pathogen-free Baboons (Papio cynocephalus anubis) Infected with Trichuris trichiura
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Efficacy of Fenbendazole Formulated in a Commercial Primate Diet for Treating Specific Pathogen-free Baboons (Papio cynocephalus anubis) Infected with Trichuris trichiura

机译：在商业灵长类动物饮食中配制的芬苯达唑用于治疗被Trichuris trichiura感染的特定无病菌狒狒（Papio cynocephalus anubis）的功效

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摘要

Trichuris trichiura is a common intestinal nematode parasite of captive baboons. We evaluated the efficacy of fenbendazole formulated in a commercial primate diet (FBZ-PD) for treating specific pathogen-free (SPF) baboons (Papio cynocephalus anubis) naturally infected with Trichuris trichiura. Twenty-nine baboons, housed indoors in 3 separate rooms, were fed FBZ-PD for 5 d, whereas 4 baboons housed in another isolated area served as untreated controls. The efficacy of FBZ-PD was measured as reduction in the number of T. trichiura eggs in host feces after treatment as determined by quantitative fecal flotation examination. All baboons that received FBZ-PD stopped shedding T. trichiura eggs by 7 d after initiation of treatment, and remained negative until at least 119 d after treatment. However, eggs of T. trichiura were present in the feces of 3 (10.3%) experimental baboons at 154 d after treatment. Untreated control baboons shed T. trichiura eggs throughout the entire study. Our results indicate that FBZ-PD was efficacious for treating SPF baboons infected with T. trichiura.
机译：Trichuris trichiura是圈养狒狒的常见肠道线虫寄生虫。我们评估了在商业灵长类动物饮食（FBZ-PD）中配制的芬苯达唑治疗自然感染Trichuris trichiura的特定无病原体（SPF）狒狒（Papio cynocephalus anubis）的功效。分别在3个单独房间的室内饲养的29只狒狒喂食FBZ-PD 5天，而在另一个隔离区域饲养的4只狒狒则作为未经处理的对照。 FBZ-PD的功效通过定量粪便浮选检查确定为处理后宿主粪便中铁锈菌卵数量的减少，从而进行测量。在开始治疗后7 d，所有接受FBZ-PD的狒狒都停止了脱落的T. trichiura卵，并一直保持阴性直到治疗后至少119 d。然而，在处理后154 d，3只（10.3％）实验狒狒的粪便中存在曲氏梭菌卵。在整个研究过程中，未经处理的狒狒脱落了毛tri虫卵。我们的结果表明，FBZ-PD可有效治疗被Trichiura感染的SPF狒狒。

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