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Preparation Characterization and Properties of Alginate/Poly(γ-glutamic acid) Composite Microparticles

机译：海藻酸盐/聚（γ-谷氨酸）复合微粒的制备表征与性能

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摘要

Alginate (Alg) is a renewable polymer with excellent hemostatic properties and biocapability and is widely used for hemostatic wound dressing. However, the swelling properties of alginate-based wound dressings need to be promoted to meet the requirements of wider application. Poly(γ-glutamic acid) (PGA) is a natural polymer with high hydrophility. In the current study, novel Alg/PGA composite microparticles with double network structure were prepared by the emulsification/internal gelation method. It was found from the structure characterization that a double network structure was formed in the composite microparticles due to the ion chelation interaction between Ca2+ and the carboxylate groups of Alg and PGA and the electrostatic interaction between the secondary amine group of PGA and the carboxylate groups of Alg and PGA. The swelling behavior of the composite microparticles was significantly improved due to the high hydrophility of PGA. Influences of the preparing conditions on the swelling behavior of the composites were investigated. The porous microparticles could be formed while compositing of PGA. Thermal stability was studied by thermogravimetric analysis method. Moreover, in vitro cytocompatibility test of microparticles exhibited good biocompatibility with L929 cells. All results indicated that such Alg/PGA composite microparticles are a promising candidate in the field of wound dressing for hemostasis or rapid removal of exudates.
机译：海藻酸盐（Alg）是具有优异止血性能和生物功能的可再生聚合物，被广泛用于止血伤口敷料。但是，需要提高藻酸盐基伤口敷料的溶胀性能，以满足更广泛应用的要求。聚（γ-谷氨酸）（PGA）是具有高亲水性的天然聚合物。在当前的研究中，通过乳化/内部凝胶化方法制备了具有双网状结构的新型Alg / PGA复合微粒。通过结构表征发现，由于Ca 2 + 与Alg和PGA的羧酸根之间的离子螯合相互作用以及次级分子之间的静电相互作用，在复合微粒中形成了双网状结构。 PGA的胺基和Alg和PGA的羧基。由于PGA的高度亲水性，复合微粒的溶胀行为得到了显着改善。研究了制备条件对复合材料溶胀行为的影响。可以在复合PGA的同时形成多孔微粒。用热重分析法研究热稳定性。此外，微粒的体外细胞相容性测试显示与L929细胞具有良好的生物相容性。所有结果表明，这种Alg / PGA复合微粒是用于止血或快速去除渗出液的伤口敷料领域的有前途的候选者。

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