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首页> 美国卫生研究院文献>ISRN Parasitology >Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria
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Impact of Eighteen-Year Varied Compliance to Onchocerciasis Treatment with Ivermectin in Sentinel Savannah Agrarian Communities in Kaduna State of Nigeria

机译：尼日利亚卡杜纳州前哨萨凡纳农业社区依维菌素治疗盘尾丝虫病十八年变化的依从性。

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Baseline and impact assessment data were generated in 1994 (n = 532) and 2011 (n = 593) from 6 sentinel villages with generalized onchocerciasis. Only volunteers and a cohort (n = 445, 75%) were screened at both visits. Each village had received 11 (64.7%) annual treatments and 92.6%, range 88.7–100%, treatment compliance. Overall mean number of treatment was 2.9 ± 1.6 with a range 2.0 ± 1.2–3.3 ± 0.6. Significant decreases in skin microfilaria prevalence from 201 (38%) to 0 (0%), palpable nodule from 77 (15%) to 4 (0.7%), dermal changes from 51 (9.6%) to 2 (0.04%), optic nerve disease from 24 (4.5%) to 4 (2.0%), and onchocercal inducible ocular lesions from 31 (5.8%) to 12 (2.0%) were recorded, P < 0.05, (t-test of unpaired data). Cases of glaucoma, 8 (1.4%), and blindness, 6 (1.05%), remained unchanged. Visual acuity ≥6/24 in one or both eyes, 198 (33.45%); cataract, 169 (28.5%); pterygium 157 (26.5%); and acute senilis, 165 (27.9%), were significantly increased and positively correlated with increase in age (R 2 = 0.898 − 0.949). Dissected parous Simulium damnosum caught (n = 222) were without infective third stage larva. Active onchocerciasis transmission seems halted despite varied compliance to long-term ivermectin treatment. We recommend continued surveillance and targeted treatment of controlled and hypoendemic areas.
机译：基线和影响评估数据分别来自1994年（n = 532）和2011（n = 593）的6个普遍存在盘尾丝虫病的前哨村庄。在两次访问中仅筛查了志愿者和队列（n = 445，75％）。每个村庄都接受了11次（64.7％）的年度治疗和92.6％的治疗依从性，范围为88.7-100％。总体平均治疗次数为2.9±1.6，范围为2.0±1.2–3.3±0.6。皮肤微丝aria病患病率从201（38％）显着降低到0（0％），明显结节从77（15％）降低到4（0.7％），皮肤变化从51（9.6％）降低到2（0.04％），视神经记录的神经疾病从24（4.5％）增至4（2.0％），并且盘尾可诱发的眼部病变从31（5.8％）增至12（2.0％），P <0.05，（未配对数据的t检验）。青光眼8例（1.4％），失明6例（1.05％）保持不变。一只或两只眼睛的视力≥6/ 24，198（33.45％）；白内障169（28.5％）;翼状肉157（26.5％）;和急性衰老者分别为165（27.9％）和年龄增长（R 2 = 0.898-0.949），并与年龄的增加呈正相关。解剖的被捕食的副产的Simulium damnosum（n = 222）没有感染性的第三阶段幼虫。尽管长期依维菌素治疗依从性不同，主动盘尾丝虫病传播似乎也停止了。我们建议继续对受控和低流行地区进行监视和有针对性的治疗。

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