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首页> 美国卫生研究院文献>Iranian Journal of Basic Medical Sciences >Assessment of HTLV-I proviral load HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection
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Assessment of HTLV-I proviral load HIV viral load and CD4 T cell count in infected subjects; with an emphasis on viral replication in co-infection

机译：评估被感染者的HTLV-1前病毒载量HIV病毒载量和CD4 T细胞计数；强调共感染中的病毒复制

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>Objective(s): HTLV-I and HIV virus quantification is an important marker for assessment of virus activities. Since there is a direct relationship between the number of virus and disease progression, HTLV-I and HIV co-infection might have an influence on the development of viral associated diseases, thus, viral replication of these viruses and co-infection were evaluated. >Materials and Methods: In this study, 40 subjects were selected; 14 HIV infected, 20 HTLV-I infected and 6 HTLV-I/HIV co-infected subjects. The amount of viruses was measured using qPCR TaqMan method and CD4 and CD8 lymphocytes were assessed by flow cytometry. >Results: The mean viral load of HIV infected subjects and HTLV-I infected individuals were 134626.07±60031.07 copies/ml and 373.6±143.3 copies/104 cells, respectively. The mean HIV viral load in co-infected group was 158947±78203.59 copies/ml which is higher than HIV infected group. The mean proviral load of HTLV-I in co-infected group was 222.33±82.56 copies/ml which is lower than HTLV-I infected group (P<0.05). Also, the mean white blood cell count was higher in co-infected group (5666.67±1146.49 cells/μl). However, the differences between these subjects did not reach to a statistical significance within 95% confidence interval level (P =0.1). No significant differences were observed regarding CD4 and CD8 positive lymphocytes between these groups. >Conclusion: HTLV-I/HIV co-infection might promote HIV replication and could reduce the HTLV-I proviral load, in infected cells. Considering the presence of both viruses in Khorasan provinces, it encourages researchers and health administrators to have a better understanding of co-infection outcome.
机译：>目标：HTLV-1和HIV病毒定量是评估病毒活性的重要标志。由于病毒数量与疾病进展之间存在直接关系，因此HTLV-1和HIV合并感染可能对病毒相关疾病的发展产生影响，因此，对这些病毒的病毒复制和合并感染进行了评估。 >材料与方法：在这项研究中，选择了40名受试者； 14名HIV感染者，20名HTLV-1感染者和6名HTLV-1 / HIV共同感染者。使用qPCR TaqMan方法测量病毒量，并通过流式细胞术评估CD4和CD8淋巴细胞。 >结果： HIV感染者和HTLV-1感染者的平均病毒载量分别为134626.07±60031.07拷贝/ ml和373.6±143.3拷贝/ 10 4 细胞。合并感染组的平均HIV病毒载量为158947±78203.59拷贝/ ml，高于HIV感染组。合并感染组中HTLV-1的平均原病毒载量为222.33±82.56拷贝/ ml，低于HTLV-1感染组（P <0.05）。同样，在共感染组中，平均白细胞计数更高（5666.67±1146.49细胞/μl）。但是，这些受试者之间的差异在95％置信区间水平内（P = 0.1）并未达到统计学显着性。这些组之间没有观察到关于CD4和CD8阳性淋巴细胞的显着差异。 >结论： HTLV-1 / HIV合并感染可能会促进HIV复制，并减少感染细胞中HTLV-1的前病毒载量。考虑到霍拉桑省同时存在两种病毒，它鼓励研究人员和卫生管理人员对共同感染的结果有更好的了解。

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