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首页> 美国卫生研究院文献>ISRN Obesity >Biomarker Profile Does Not Predict Weight Loss Success in Successful and Unsuccessful Diet-Reduced Obese Individuals: A Prospective Study
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Biomarker Profile Does Not Predict Weight Loss Success in Successful and Unsuccessful Diet-Reduced Obese Individuals: A Prospective Study

机译：生物标记物谱不能预测成功和不成功的饮食减少的肥胖个体的减肥成功：一项前瞻性研究

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Background. Individuals attempting weight reduction have varying success when participating in the same intervention. Identifying physiological factors associated with greater weight loss could improve outcomes. Methods. Sixty-one adults (BMI 27–30 kg/m2) participated in a 16-week group-based, cognitive-behavioral control weight loss program. Concentrations of 12 fasting hormones and cytokines related to adiposity, satiety/hunger, and inflammation were measured using the Milliplex human metabolic human panel before and after weight loss. Participants were grouped based on ≥8% (successful group, SG) or <8% weight loss (less successful group, LSG). Results. The SG had 46 subjects (75.4%), while the LSG had 15 (24.6%). There were no differences in baseline sex distribution, age, weight, BMI, and body composition between groups. In the SG, baseline to the 16-week levels decreased significantly for c-peptide (1,030 versus 891 pg/mL, P = 0.002), insulin (665 versus 541 pg/mL, P = 0.001), and leptin (0.83 versus 0.58 ng/mL/kg fat, P < 0.001). None of the baseline analytes predicted greater weight loss. Conclusions. Successful weight loss was associated with changes in adiposity (less fat mass) and unfavorable hunger signals. No baseline biomarker profile was associated with weight loss success. Behavioral factors may have outweighed physiological signals for determining successful weight loss. This trial is registered with Clinicaltrials.gov .
机译：背景。尝试减肥的个体在参加相同的干预措施时会有不同的成功。确定与更大的体重减轻相关的生理因素可以改善预后。方法。六十一名成年人（BMI 27–30 kg / m 2 ）参加了为期16周的基于小组的认知行为控制减肥计划。在减肥之前和之后，使用Milliplex人体代谢人类研究小组测量与肥胖，饱腹感/饥饿和炎症相关的12种空腹激素和细胞因子的浓度。参与者根据≥8％（成功组，SG）或体重减轻<8％（成功率较低的组，LSG）分组。结果。 SG有46名受试者（75.4％），而LSG有15名（24.6％）。两组之间的基线性别分布，年龄，体重，BMI和身体组成无差异。在SG中，c肽（1,030对891 pg / mL，P = 0.002），胰岛素（665对541μpg/ mL，P = 0.001）和瘦素（16:34的基线水平）显着降低（0.83对0.58） ng / mL / kg脂肪，P <0.001）。基线分析物均未预测更大的重量损失。结论。成功的体重减轻与肥胖症的变化（脂肪量减少）和饥饿信号不利相关。没有基线生物标志物谱与减肥成功相关。行为因素可能胜过生理信号，无法确定成功的减肥效果。该试验已在Clinicaltrials.gov上注册。

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