首页> 美国卫生研究院文献>ISRN Gastroenterology >Are Dysregulated Inflammatory Responses to Commensal Bacteria Involved in the Pathogenesis of Hepatobiliary-Pancreatic Autoimmune Disease? An Analysis Using Mice Models of Primary Biliary Cirrhosis and Autoimmune Pancreatitis
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Are Dysregulated Inflammatory Responses to Commensal Bacteria Involved in the Pathogenesis of Hepatobiliary-Pancreatic Autoimmune Disease? An Analysis Using Mice Models of Primary Biliary Cirrhosis and Autoimmune Pancreatitis

机译:对共生细菌的炎症反应异常是否参与肝胆胰腺自身免疫性疾病的发病机制?利用原发性胆汁性肝硬化和自身免疫性胰腺炎的小鼠模型进行分析

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摘要

The etiopathogenesis of many autoimmune disorders has not been identified. The aim of this paper is to focus on the involvement of bacterial exposure in the pathogenesis of primary biliary cirrhosis (PBC) and autoimmune pancreatitis (AIP), both of which are broadly categorized as autoimmune disorders involving hepatobiliary-pancreatic lesions. Avirulent and/or commensal bacteria, which may have important role(s) as initiating factors in the pathogenesis of autoimmune disorders such as PBC and AIP, will be emphasized.
机译:许多自身免疫性疾病的病因尚未确定。本文的目的是集中于细菌暴露与原发性胆汁性肝硬化(PBC)和自身免疫性胰腺炎(AIP)的发病机理有关,这两种疾病都被广泛归类为涉及肝胆胰病变的自身免疫性疾病。将强调无毒和/或共生细菌,它们可能是自身免疫性疾病(例如PBC和AIP)发病机理中的重要起因。

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