• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>ACS Omega >Electrospun Poly(ε-caprolactone)Fiber Scaffolds Functionalized by the Covalent Grafting of a BioactivePolymer: Surface Characterization and Influence on in Vitro BiologicalResponse
【2h】

Electrospun Poly(ε-caprolactone)Fiber Scaffolds Functionalized by the Covalent Grafting of a BioactivePolymer: Surface Characterization and Influence on in Vitro BiologicalResponse

机译：电纺聚ε-己内酯通过生物活性物的共价接枝功能化的纤维支架。聚合物：表面表征及其对体外生物学的影响响应

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The purpose of this study is to present the poly(caprolactone) (PCL) functionalization by the covalent grafting of poly(sodium styrene sulfonate) on electrospun scaffolds using the “grafting from” technique and evaluate the effect of the coating and surface wettability on the biological response. The “grafting from” technique required energy (thermal or UV) to induce the decomposition of the PCL (hydro)peroxides and generate radicals able to initiate the polymerization of NaSS. In addition, UV irradiation was used to initiate the radical polymerization of NaSS directly from the surface (UV direct “grafting from”). The interest of these two techniques is their easiness, the reduction of the number of process steps, and its applicability to the industry. The selected parameters allow controlling the grafting rate (i.e., degree of functionalization). The aim of the study was to compare two covalent grafting in terms of surface functionalization and hydrophilicity and their effect on the in vitro biological responses of fibroblasts. The achieved results showed the influence of the sulfonate functionalgroups on the cell response. In addition, outcomes highlighted thatthe UV direct “grafting from” method allows to moderatethe amount of sulfonate groups and the surface hydrophilicity presentsa considerable interest for covalently immobilizing bioactive polymersonto electrospun scaffolds designed for tissue engineering applicationsusing efficient post-electrospinning chemical modification.
机译：本研究的目的是通过“嫁接自”技术，通过将聚苯乙烯磺酸钠共价接枝到电纺支架上，介绍聚己内酯（PCL）的官能化作用，并评估涂层和表面润湿性对涂料的影响。生物反应。 “接枝”技术需要能量（热能或紫外线）来诱导PCL（氢）过氧化物的分解并产生能够引发NaSS聚合的自由基。另外，使用紫外线辐射直接从表面引发NaSS的自由基聚合（直接从紫外线“嫁接”）。这两种技术的兴趣在于它们的简便性，减少的工艺步骤数量及其在工业上的适用性。所选择的参数允许控制接枝率（即官能化程度）。该研究的目的是比较两种共价接枝的表面功能化和亲水性，以及它们对成纤维细胞体外生物学反应的影响。所获得的结果表明了磺酸盐官能团的影响。组对细胞的反应。此外，结果强调UV直接“嫁接自”方法可以适度磺酸根基团的数量和表面亲水性对共价固定生物活性聚合物有很大的兴趣用于组织工程应用的电纺支架上使用高效的静电纺丝后化学修饰。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号