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首页> 美国卫生研究院文献>Iranian Journal of Pharmaceutical Research : IJPR >Evaluation of the Antimalarial Effect of Ferulago angulata (Schlecht.) Boiss. Extract and Suberosin Epoxide Against Plasmodium berghei in Comparison with Chloroquine Using in-vivo Test
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Evaluation of the Antimalarial Effect of Ferulago angulata (Schlecht.) Boiss. Extract and Suberosin Epoxide Against Plasmodium berghei in Comparison with Chloroquine Using in-vivo Test

机译：Ferulago angulata（Schlecht。）Boiss的抗疟作用评估。使用氯吡喹和氯喹的体内提取物和超环氧化物对伯氏疟原虫的比较

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摘要

Resistance to most antimalarial drugs has encouraged the development of novel drugs. An alternative source for discovering such drugs is natural products. Some Ferulago species are used in folk medicine for their sedative, tonic and anti-parasitic effects. Besides, coumarins isolated from this genus found to have in vitro anti-leishmanicidal effect. The present study is aimed to evaluate the in-vivo antimalarial activity of Ferulago angulata (Schlecht.) Boiss. extract and suberosin epoxide, using suarian mice. A rodent malaria parasite, Plasmodium berghei was used to inoculate healthy male Swiss Albino mice of age 6-8 weeks and weight 23-27 g. Hydro-alcoholic extract of F. angulata (20, 100, 300, 600 mg/Kg) and suberosin epoxide suspension (10, 30, 50, 100 mg/Kg) were administered subcutaneously. Parameters including percentage of parasitemia, suppression of parasitemia and mean survival time were determined using standard test such as peter٬s.Chemo-protective effects were exerted by the crude extract and suberosin epoxide. Maximum effect was observed with the larger doses of the crude extract and suberosin epoxide. Suberosin epoxide increased the survival time compared to chloroquine. However, the results of this study indicate that the plant has a promising anti-plasmodial activity against plasmodium berghei. Thus, it could be considered as a potential source of new antimalarial agents. Suberosin epoxide at the dose of 100 mg/Kg possesses relatively significant antimalarial effect. Chemical derivatization of the parent compound or preparation of the modified formulation is required to improve its systemic bioavailability.
机译：对大多数抗疟疾药物的耐药性促进了新药的开发。发现此类药物的另一种来源是天然产物。 Ferulago的某些物种因其镇静，滋补和抗寄生虫作用而被用于民间医学。此外，从该属中分离出的香豆素具有体外的抗杀菌作用。本研究旨在评估Ferulago angulata（Schlecht。Boiss）的体内抗疟活性。提取物，然后使用苏利亚小鼠。使用啮齿类疟疾寄生虫柏氏疟原虫接种6-8周龄，体重23-27 g的健康雄性瑞士白化病小鼠。皮下给予安祖花的水-醇提取物（20、100、300、600mg / Kg）和亚松脂环氧化物悬浮液（10、30、50、100mg / Kg）。用标准试验如peter ， s确定包括寄生虫百分率，寄生虫抑制率和平均存活时间在内的参数。粗提物和亚新城环氧化物具有化学保护作用。较大剂量的粗提物和亚松脂环氧化物观察到最大的效果。与氯喹相比，环氧环松脂可延长生存时间。但是，这项研究的结果表明该植物对伯氏疟原虫具有有希望的抗疟原虫活性。因此，它可以被认为是新的抗疟药的潜在来源。 100 mg / Kg剂量的亚油溶环氧化物具有相对显着的抗疟作用。需要母体化合物的化学衍生或修饰制剂的制备以提高其全身生物利用度。

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