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首页> 美国卫生研究院文献>Interdisciplinary Toxicology >Toxic effect of sodium fluoride on hydroxyproline level and expression of collagen-1 gene in rat bone and its amelioration by Tamrindus indica L. fruit pulp extract
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Toxic effect of sodium fluoride on hydroxyproline level and expression of collagen-1 gene in rat bone and its amelioration by Tamrindus indica L. fruit pulp extract

机译：氟化钠对大鼠骨骼中羟脯氨酸水平和胶原-1基因表达的毒理作用及其淡淡坦姆杜斯果肉提取物的改善作用

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摘要

Excessive fluoride intoxication plays an important role in the development of dental, skeletal and non-skeletal fluorosis. The aim of this study was to ascertain the toxic effect of excessive fluoride ingestion on the level of hydroxyproline and expression of type 1 collagen gene in rat bone and its amelioration by supplementation with Tamarindus indica fruit pulp extract. Forty albino rats were randomly assigned to four groups. The first group served as control and received only tap water. The second group received sodium fluoride (200 ppm) through drinking water. The third group received T. indica fruit pulp extract (200 mg/kg body weight) alone and the fourth group received the T. indica fruit pulp extract (200 mg/kg body weight) along with fluorinated drinking water (200 ppm) daily by gavage for a period of 90 days. The level of hydroxyproline and expression of type 1 collagen gene using quantitative real time PCR in the tibia bone decreased significantly with continuous exposure to sodium fluoride. Co-administration of T. indica fruit pulp extract during exposure to fluoride through drinking water restored the level of calcium, phosphorus and alkaline phosphatase in serum and the concentration of hydroxyproline in urine. It increased the level of hydroxyproline and expression of type 1 collagen gene in the tibia as compared to untreated fluoride-exposed rats. It is concluded that T. indica fruit pulp extract has an ameliorative potential to protect the bone from fluoride induced collagen damage.
机译：过量的氟化物中毒在牙齿，骨骼和非骨骼氟中毒的发展中起着重要作用。这项研究的目的是确定过量摄入氟化物对大鼠骨骼中羟脯氨酸水平和1型胶原基因表达的毒性作用，并补充罗望子du实果肉提取物来改善其含量。将40只白化病大鼠随机分为四组。第一组作为对照组，仅接受自来水。第二组通过饮用水接受氟化钠（200 ppm）。第三组每天分别接受T实果肉提取物（200 mg / kg体重），第四组每天接受T实果肉提取物（200 mg / kg体重）和氟化饮用水（200 ppm）。管管为期90天。连续暴露于氟化钠中，使用实时荧光定量PCR检测胫骨中的羟脯氨酸水平和1型胶原基因表达。 drinking果浆提取物在通过饮用水暴露于氟化物期间的共同给药可恢复血清中钙，磷和碱性磷酸酶的水平以及尿液中羟脯氨酸的浓度。与未处理氟化物的大鼠相比，它增加了胫骨中羟脯氨酸的水平和1型胶原基因的表达。结论是T树果肉提取物具有保护骨骼免受氟化物诱导的胶原蛋白损伤的改善潜力。

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