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Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

机译：改良的秀丽隐杆线虫的淀粉样β（Aβ1-42）毒性模型在筛选阿尔茨海默氏病药物中的用途

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摘要

BackgroundThe definitive indicator of Alzheimer’s disease (AD) pathology is the profuse accumulation of amyloid-ß (Aß) within the brain. Various in vitro and cell-based models have been proposed for high throughput drug screening for potential therapeutic benefit in diseases of protein misfolding. Caenorhabditis elegans offers a convenient in vivo system for examination of Aß accumulation and toxicity in a complex multicellular organism. Ease of culturing and a short life cycle make this animal model well suited to rapid screening of candidate compounds.

机译：背景阿尔茨海默氏病（AD）病理的确定指标是脑内淀粉样β（Aß）的大量积累。已经提出了各种体外和基于细胞的模型用于高通量药物筛选，以用于蛋白质错折叠疾病的潜在治疗益处。秀丽隐杆线虫提供了一种方便的体内系统，用于检查复杂的多细胞生物中的Aß积累和毒性。易于培养和较短的生命周期使该动物模型非常适合快速筛选候选化合物。

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期刊名称 Molecular Neurodegeneration
作者
Gawain McColl; Blaine R Roberts; Tara L Pukala; Vijaya B Kenche; Christine M Roberts; Christopher D Link; Timothy M Ryan; Colin L Masters; Kevin J Barnham; Ashley I Bush; Robert A Cherny;
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作者单位

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年(卷),期 2012(7),-1
年度 2012
页码 57
总页数 9
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Amyloid beta peptide Alzheimer’s disease Caenorhabditis elegans 8-hydroxyquinoline PBT2 and drug screen;

机译：淀粉样β肽;阿尔茨海默氏病;秀丽隐杆线虫;8-羟基喹啉;PBT2和药物筛选;

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专利

1. Utility of an improved model of amyloid-beta (Aβ_1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease [J] . Gawain McColl, Blaine R Roberts, Tara L Pukala, Molecular neurodegeneration . 2012,第S1期

机译：改良的秀丽隐杆线虫淀粉样β（Aβ_{1-42 ）毒性模型在筛选阿尔茨海默氏病药物中的应用}
2. Utility of an improved model of amyloid-beta (Aβ_1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease [J] . Gawain McColl, Blaine R Roberts, Tara L Pukala, Molecular neurodegeneration . 2012,第S1期

机译：改良的秀丽隐杆线虫淀粉样β（Aβ_{1-42 ）毒性模型在筛选阿尔茨海默氏病药物中的应用}
3. Oxoisoaporphine alkaloid derivative 8-1 reduces A beta(1-42) secretion and toxicity in human cell and Caenorhabditis elegans models of Alzheimer's disease [J] . Huang Liyingzi, Luo Yunfeng, Pu Zhijun, Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2017,第期

机译：Oxoisoaporphine生物碱衍生物8-1减少了人细胞和塞伦米塞氏病的人细胞和Caenorhabditis的胃肠杆菌中的β（1-42）分泌和毒性
4. Using Caenorhabditis elegans as a Model for Aging and Age-Related Diseases [C] . ANDERS OLSEN, MAITHILI C. VANTIPALLI, GORDON J. LITHGOW, International Association of Biomedical Gerontology International . 2006

机译：使用CaenorhabditiseDeltans作为衰老和年龄相关疾病的模型
5. Vitamin B12 Deficiency Does Not Stimulate Amyloid-Beta Toxicity in a Ceanorhabditis Elegans Model of Alzheimer’s Disease [D] . Showemimo, Opeyemi F. 2021

机译：维生素B12缺乏在阿尔茨海默病的Ceanorhabdisegans模型中没有刺激淀粉样蛋白β毒性
6. Cranberry Extract Standardized for Proanthocyanidins Alleviates β-Amyloid Peptide Toxicity by Improving Proteostasis Through HSF-1 in Caenorhabditis elegans Model of Alzheimer’s Disease [O] . Hong Guo, Min Cao, Sige Zou, -1

机译：原花青素标准化的蔓越莓提取物通过通过HSF-1改善线粒体秀丽隐杆线虫模型中的蛋白质稳态来减轻β-淀粉样蛋白肽的毒性。
7. Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease [O] . Gawain McColl, Blaine R Roberts, Tara L Pukala, 2012

机译：改良的秀丽隐杆线虫的淀粉样β（Aβ1-42）毒性模型在筛选阿尔茨海默氏病药物中的用途

Utility of an improved model of amyloid-beta (Aβ1-42) toxicity in Caenorhabditis elegans for drug screening for Alzheimer’s disease

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