Concise Review: Differentiation of Human Adult Stem Cells Into Hepatocyte-like Cells In vitro

机译：简洁评论：体外将人类成年干细胞分化为类肝细胞

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摘要

Adult stem cells (ASCs) are undifferentiated cells found throughout the body that divide to replenish dying cells and regenerate damaged tissues, which are the powerful sources for cell therapy and tissue engineering. Bone marrow-derived mesenchymal stem cells (BMSCs), adipose tissue-derived mesenchymal stem cells (ADSCs), and peripheral blood monocytes (PBMCs) are the common ASCs, and many studies indicated that ASCs isolated from various adult tissues could be induced to hepatocyte-like cells in vitro. However, the isolation, culture protocols, characterization of ASCs and hepatocyte-like cells are different. This review aims to describe the isolation and culture procedures for ASCs, to summarize the molecular characterization of ASCs, to characterize function of hepatocyte-like cells, and to discuss the future role of ASCs in cell therapy and tissue engineering.

机译：成人干细胞（ASC）是遍布全身的未分化细胞，它们分裂后可补充垂死的细胞并再生受损的组织，这是细胞疗法和组织工程的强大动力。骨髓来源的间充质干细胞（BMSC），脂肪组织来源的间充质干细胞（ADSC）和外周血单核细胞（PBMC）是常见的ASC，许多研究表明，从各种成人组织中分离得到的ASC均可被诱导为肝细胞样细胞。但是，ASC和肝细胞样细胞的分离，培养方案，特征不同。这篇综述旨在描述ASC的分离和培养程序，总结ASC的分子特征，表征肝细胞样细胞的功能，并讨论ASC在细胞治疗和组织工程中的未来作用。

著录项

期刊名称 International Journal of Stem Cells
作者
Yunwei Zhang; Lijuan Xu; Shufang Wang; Changhao Cai; Li Yan;
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作者单位

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年(卷),期 2014(7),2
年度 2014
页码 49–54
总页数 6
原文格式 PDF
正文语种
中图分类细胞生物学;
关键词
Adult stem cells Bone marrow-derived mesenchymal stem cells Adipose tissue-derived mesenchymal stem cells Peripheral blood monocytes Hepatocyte-like cells;

机译：成体干细胞;骨髓源间充质干细胞;脂肪组织源间充质干细胞外周血单核细胞;类肝细胞;

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专利

1. Sequential exposure to cytokines reflecting embryogenesis: the key for in vitro differentiation of adult bone marrow stem cells into functional hepatocyte-like cells. [J] . Snykers S, Vanhaecke T, Papeleu P, Toxicological sciences: An official journal of the Society of Toxicology . 2006,第2期

机译：顺序暴露于反映胚胎发生的细胞因子：成年骨髓干细胞体外分化为功能性肝细胞样细胞的关键。
2. Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for in vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-like Cells [J] . Sarah Snykers, Tamara Vanhaecke, Peggy Papeleu, Toxicological Sciences . 2006,第2期

机译：顺序暴露于反映胚胎发生的细胞因子：成年骨髓干细胞体外分化为功能性肝细胞样细胞的关键
3. Sequential Exposure to Cytokines Reflecting Embryogenesis: The Key for In Vitro Differentiation of Adult Bone Marrow Stem Cells into Functional Hepatocyte-Like Cells [J] . Zoran Ilic, Hyam Leffert† and Stewart Sell‡ Toxicological Sciences . 2006,第2期

机译：顺序暴露于反映胚胎发生的细胞因子：成年骨髓干细胞体外分化为功能性肝细胞样细胞的关键
4. 3D Transdifferentiation of Human Mesenchymal Stem Cells into Hepatocyte-Like Cells Using Bioprinted Scaffolds [C] . Chien KB, Jakus AE, Shah RN Society for Biomaterials annual meeting and exposition . 2013

机译：使用生物印染的支架将人间充质干细胞从3D转分化为类肝细胞
5. Evaluating the capacity of adult human mesenchymal stem cells to differentiate into insulin-producing cells in vitro [D] . Ratanshi, Imran 2009

机译：评估成人间充质干细胞体外分化为产生胰岛素的细胞的能力
6. Stem Cells from Cryopreserved Human Dental Pulp Tissues Sequentially Differentiate into Definitive Endoderm and Hepatocyte-Like Cells in vitro [O] . Young-Jin Han, Young-Hoon Kang, Sarath Belame Shivakumar, 2017

机译：冷冻保存的人类牙髓组织的干细胞在体外依次分化为定形内胚层和肝细胞样细胞
7. Concise Review: Differentiation of Human Adult Stem Cells Into Hepatocyte-like Cells In vitro [O] . Yunwei Zhang, Lijuan Xu, Shufang Wang, 2014

机译：简明审查：将人成人干细胞的分化在体外分化成肝细胞样细胞

Concise Review: Differentiation of Human Adult Stem Cells Into Hepatocyte-like Cells In vitro

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