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首页> 美国卫生研究院文献>International Journal of Oral Science >Divide and conquer: two stem cell populations in squamous epithelia reserves and the active duty forces
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Divide and conquer: two stem cell populations in squamous epithelia reserves and the active duty forces

机译：分而治之：鳞状上皮储备区和现役部队中的两个干细胞种群

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Stem cells are of great interest to the scientific community due to their potential role in regenerative and rejuvenative medicine. However, their role in the aging process and carcinogenesis remains unclear. Because DNA replication in stem cells may contribute to the background mutation rate and thereby to cancer, reducing proliferation and establishing a relatively quiescent stem cell compartment has been hypothesized to limit DNA replication-associated mutagenesis. On the other hand, as the main function of stem cells is to provide daughter cells to build and maintain tissues, the idea of a quiescent stem cell compartment appears counterintuitive. Intriguing observations in mice have led to the idea of separated stem cell compartments that consist of cells with different proliferative activity. Some epithelia of short-lived rodents appear to lack quiescent stem cells. Comparing stem cells of different species and different organs (comparative stem cell biology) may allow us to elucidate the evolutionary pressures such as the balance between cancer and longevity that govern stem cell biology (evolutionary stem cell biology). The oral mucosa and its stem cells are an exciting model system to explore the characteristics of quiescent stem cells that have eluded biologists for decades.
机译：干细胞由于其在再生医学和再生医学中的潜在作用而引起了科学界的极大兴趣。然而，它们在衰老过程和致癌作用中的作用仍不清楚。由于干细胞中的DNA复制可能会导致背景突变率增加，进而导致癌症，因此，有人提出减少增殖并建立相对静止的干细胞区室来限制与DNA复制相关的诱变。另一方面，由于干细胞的主要功能是提供子细胞来建立和维持组织，因此，静态干细胞区室的想法似乎违反直觉。小鼠中有趣的观察结果导致了分离干细胞隔室的想法，该干细胞隔室由具有不同增殖活性的细胞组成。短寿命啮齿动物的某些上皮细胞似乎缺乏静止的干细胞。比较不同物种和不同器官的干细胞（比较干细胞生物学）可能使我们能够阐明进化压力，例如控制干细胞生物学（进化干细胞生物学）的寿命和寿命之间的平衡。口腔粘膜及其干细胞是一个令人兴奋的模型系统，用于探索生物学家数十年来一直lude默的静态干细胞的特征。

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