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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis
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Human serum albumin nanoparticles as an efficient noscapine drug delivery system for potential use in breast cancer: preparation and in vitro analysis

机译：人血清白蛋白纳米颗粒可作为有效的Noscapine药物递送系统可在乳腺癌中潜在使用：制备和体外分析

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摘要

Drug delivery systems such as nanoparticles can provide enhanced efficacy for anticancer agents. Noscapine, a widely used cough suppressant for decades has recently been shown to cause significant inhibition and regression of tumor volumes without any detectable toxicity in cells or tissues. Nanoparticles made of human serum albumin (HSA) represent promising strategy for targeted drug delivery to tumor cells by enhancing the drug’s bioavailability and distribution, and reducing the body’s response towards drug resistance. In the present study, we report for the first time the incorporation and delivery of noscapine-loaded HSA nanoparticles to tumor cells. The nanoparticles were designed and optimized to achieve a particle size in the range of 150–300 nm with a drug-loading efficiency of 85%–96%. The nanoparticles were evaluated in vitro for their anticancer activity and efficacy on breast cancer cells.
机译：诸如纳米颗粒的药物递送系统可以为抗癌药提供增强的功效。 Noscapine是数十年来被广泛使用的止咳药，最近已显示出对肿瘤体积的显着抑制和消退，而在细胞或组织中没有任何可检测的毒性。由人类血清白蛋白（HSA）制成的纳米颗粒通过增强药物的生物利用度和分布并减少人体对耐药性的反应，代表了靶向药物向肿瘤细胞递送的有前途的策略。在本研究中，我们首次报道了装载有Noscapine的HSA纳米颗粒的掺入和向肿瘤细胞的递送。设计和优化了纳米颗粒，以实现150-300 nm范围内的粒径，载药效率为85％-96％。在体外评估纳米颗粒对乳腺癌细胞的抗癌活性和功效。

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