Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo

机译：曲妥珠单抗和Fab片段修饰的姜黄素PEG-PLGA纳米颗粒：体内和体外的制备和评估

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IntroductionNanoparticles (NPs) modified with bio-ligands represent a promising strategy for active targeted drug delivery to tumour. However, many targeted ligands, such as trastuzumab (TMAB), have high molecular weight, limiting their application for targeting. In this study, we prepared Fab’ (antigen-binding fragments cut from TMAB)-modified NPs (Fab′-NPs) with curcumin (Cur) as a model drug for more effective targeting of human epidermal growth factor receptor 2 (HER2/ErbB2/Neu), which is overexpressed on breast cancer cells.

机译：简介用生物配体修饰的纳米颗粒（NPs）是一种主动靶向药物转移至肿瘤的有前途的策略。但是，许多靶向配体（例如曲妥珠单抗（TMAB））具有高分子量，限制了其在靶向中的应用。在这项研究中，我们制备了用姜黄素（Cur）作为模型药物的Fab'（从TMAB切割而来的抗原结合片段）修饰的NP（Fab'-NP），以更有效地靶向人表皮生长因子受体2（HER2 / ErbB2 / Neu），在乳腺癌细胞中过表达。

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期刊名称 International Journal of Nanomedicine
作者
Dongyu Duan; Aiping Wang; Ling Ni; Liping Zhang; Xiuju Yan; Ying Jiang; Hongjie Mu; Zimei Wu; Kaoxiang Sun; Youxin Li;
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作者单位

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年(卷),期 2018(13),-1
年度 2018
页码 1831–1840
总页数 10
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
trastuzumab-modified curcumin nanoparticles Fab′-modified curcumin nanoparticles pharmacokinetics biodistribution tumour targeting breast cancer;

机译：曲妥珠单抗修饰的姜黄素纳米颗粒;Fab修饰的姜黄素纳米颗粒;药代动力学;生物分布;肿瘤靶向;乳腺癌;

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专利

1. Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo [J] . Dongyu Duan, Aiping Wang, Ling Ni, International Journal of Nanomedicine . 2018,第1期

机译：曲妥珠单抗和Fab'片段修饰的姜黄素PEG-PLGA纳米颗粒：体内和体外的制备和评估
2. Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation [J] . Sanyuan Hu, Yangde Zhang International Journal of Nanomedicine . 2010,第6期

机译：装载Endostar的PEG-PLGA纳米颗粒：体外和体内评估
3. Tumor necrosis factor alpha blocking peptide loaded PEG-PLGA nanoparticles: preparation and in vitro evaluation. [J] . Yang A, Yang L, Liu W, International Journal of Pharmaceutics . 2007,第1期

机译：载有肿瘤坏死因子α阻断肽的PEG-PLGA纳米颗粒：制备和体外评估。
4. PACLITAXEL-LOADED POLYMERIC NANOPARTICLES BASED ON PCL-PEG-PCL:PREPARATION, IN VITRO AND IN VIVO EVALUATION [C] . Linhua Zhang, Yingna He, Mei Yu, Symposium on innovative polymers for controlled delivery: Abstract book. . 2010

机译：基于PCL-PEG-PCL的以帕拉西他为负载的聚合物纳米颗粒的制备：体外和体内评价
5. Preparation and in Vitro, in Vivo Evaluation of 5-Fluorouracil Using Novel Delivery Systems of Colorectal Cancer Treatment [D] . Smith, Taylor A. 2020

机译：制备和体外，体内评价5-氟尿嘧啶，使用结直肠癌治疗新型递送系统
6. Endostar-loaded PEG-PLGA nanoparticles: in vitro and in vivo evaluation [O] . Sanyuan Hu, Yangde Zhang 2010

机译：装载Endostar的PEG-PLGA纳米颗粒：体外和体内评估
7. Trastuzumab- and Fabprime; fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo [O] . Dongyu Duan, Aiping Wang, Ling Ni, 2018

机译：Trastuzumab-和Fab'片段改性姜黄素PEG-PLGA纳米颗粒：体外制备和评估和体内

Trastuzumab- and Fab′ fragment-modified curcumin PEG-PLGA nanoparticles: preparation and evaluation in vitro and in vivo

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