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Silver nanoparticles induced alterations in multiple cellular targets which are critical for drug susceptibilities and pathogenicity in fungal pathogen (Candida albicans)

机译:银纳米颗粒诱导多个细胞靶标的改变这对于真菌病原体(白色念珠菌)的药敏性和致病性至关重要

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摘要

PurposeA significant increase in the incidence of fungal infections and drug resistance has been observed in the past decades due to limited availability of broad-spectrum antifungal drugs. Nanomedicines have shown significant antimicrobial potential against various drug-resistant microbes. Silver nanoparticles (AgNps) are known for their antimicrobial properties and lower host toxicity; however, for clinical applications, evaluation of their impact at cellular and molecular levels is essential. The present study aims to understand the cellular and molecular mechanisms of AgNp-induced toxicity in a common fungal pathogen, Candida albicans.
机译:目的由于广谱抗真菌药物的可用性有限,在过去的几十年中,真菌感染和耐药性的发生率显着增加。纳米药物已显示出对各种耐药微生物的显着抗菌潜力。银纳米颗粒(AgNps)以其抗菌性能和较低的宿主毒性而著称。但是,对于临床应用而言,评估它们在细胞和分子水平上的影响至关重要。本研究旨在了解在常见的真菌病原体白色念珠菌中,AgNp诱导的毒性的细胞和分子机制。

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