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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Nanoporosity improved water absorption in vitro degradability mineralization osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate
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Nanoporosity improved water absorption in vitro degradability mineralization osteoblast responses and drug release of poly(butylene succinate)-based composite scaffolds containing nanoporous magnesium silicate compared with magnesium silicate

机译：纳米多孔性改善了纳米多孔硅酸镁与硅酸镁相比的聚丁二酸丁二醇酯基复合支架的吸水性体外降解性矿化性成骨细胞响应和药物释放

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摘要

Bioactive composite macroporous scaffold containing nanoporosity was prepared by incorporation of nanoporous magnesium silicate (NMS) into poly(butylene succinate) (PBSu) using solvent casting–particulate leaching method. The results showed that the water absorption and in vitro degradability of NMS/PBSu composite (NMPC) scaffold significantly improved compared with magnesium silicate (MS)/PBSu composite (MPC) scaffold. In addition, the NMPC scaffold showed improved apatite mineralization ability, indicating better bioactivity, as the NMPC containing nanoporosity could induce more apatite and homogeneous apatite layer on the surfaces than MPC scaffold. The attachment and proliferation of MC3T3-E1 cells on NMPC scaffold increased significantly compared with MPC scaffold, and the alkaline phosphatase (ALP) activity of the cells on NMPC scaffold was expressed at considerably higher levels compared with MPC scaffold. Moreover, NMPC scaffold with nanoporosity not only had large drug loading (vancomycin) but also exhibited drug sustained release. The results suggested that the incorporation of NMS into PBSu could produce bioactive composite scaffold with nanoporosity, which could enhance water absorption, degradability, apatite mineralization and drug sustained release and promote cell responses.
机译：通过使用溶剂流延-颗粒浸出法将纳米多孔硅酸镁（NMS）掺入聚丁二酸丁二酸酯（PBSu）中来制备具有纳米多孔性的生物活性复合大孔支架。结果表明，与硅酸镁（MS）/ PBSu复合材料（MPC）支架相比，NMS / PBSu复合材料（NMPC）支架的吸水率和体外降解性显着提高。此外，NMPC支架显示出改善的磷灰石矿化能力，表明具有更好的生物活性，因为与MPC支架相比，包含纳米孔隙的NMPC可以在表面诱导更多的磷灰石和均匀的磷灰石层。与MPC支架相比，MC3T3-E1细胞在NMPC支架上的附着和增殖显着增加，并且在MPC支架上的细胞碱性磷酸酶（ALP）活性比MPC支架高得多。此外，具有纳米多孔性的NMPC支架不仅具有大的药物载量（万古霉素），而且还具有药物的持续释放。结果表明，将NMS掺入PBSu可以制备具有纳米孔隙的生物活性复合支架，从而可以增强水的吸收，降解，磷灰石矿化和药物缓释并促进细胞反应。

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