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Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique characterization pharmacokinetics and evaluation of inhibitory effect on HepG2 cells

机译：液体反溶剂沉淀技术制备厚朴酚纳米颗粒表征药代动力学和对HepG2细胞抑制作用的评估

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摘要

BackgroundHonokiol is a bioactive lignanoid and has been utilized in traditional Chinese medicine for a long time. It exhibits several pharmacological properties, such as anticancer effects, anti-inflammatory effects, and antianxiety effects. However, the poor aqueous solubility of honokiol has impeded clinical applications.

机译：背景厚朴酚是一种具有生物活性的木脂素，已在中药中使用了很长时间。它具有多种药理特性，例如抗癌作用，抗炎作用和抗焦虑作用。然而，厚朴酚的不良水溶性阻碍了临床应用。

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期刊名称 International Journal of Nanomedicine
作者
Weiwei Wu; Li Wang; Lingling Wang; Yuangang Zu; Siying Wang; Peiyan Liu; Xiuhua Zhao;
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作者单位

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年(卷),期 2018(13),-1
年度 2018
页码 5469–5483
总页数 15
原文格式 PDF
正文语种
中图分类生化遗传学;生化药理学;
关键词
honokiol honokiol nanoparticles solubility bioavailability;

机译：厚朴酚;厚朴酚纳米颗粒;溶解度;生物利用度;

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专利

1. Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique, characterization, pharmacokinetics, and evaluation of inhibitory effect on HepG2 cells [J] . Weiwei Wu, Li Wang, Lingling Wang, International Journal of Nanomedicine . 2018,第1期

机译：液体反溶剂沉淀技术制备厚朴酚纳米颗粒，表征，药代动力学和对HepG2细胞抑制作用的评估
2. Preparation, characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique [J] . Weiwei Wu, Yuangang Zu, Li Wang, Drug delivery. . 2017,第1期

机译：液体抗溶剂沉淀技术制备芹菜素纳米粒的制备，表征及抗肿瘤活性评价
3. Preparation, characterization and antitumor activity evaluation of silibinin nanoparticles for oral delivery through liquid antisolvent precipitation [J] . Wu Weiwei, Zu Yuangang, Wang Lingling, RSC Advances . 2017,第86期

机译：通过液体抗溶剂沉淀的口服递送硅蛋白纳米蛋白纳米粒子的制备，表征和抗肿瘤活性评价
4. Preparation and Evaluation of Paclitaxel Nano- and Microparticle by Supercritical Antisolvent Precipitation Process [C] . Controlled Release Society annual meeting . 2004

机译：超临界抗溶解沉淀法制备紫杉醇纳米和微粒的制备与评价
5. Preparation, characterization and evaluation of dissolution of nanoparticles made by precipitation in drug carrier pores. [D] . Kokil, Suruchi N. 2009

机译：通过在药物载体孔中沉淀制备的纳米颗粒的制备，表征和评估。
6. Preparation characterization and antitumor activity evaluation of apigenin nanoparticles by the liquid antisolvent precipitation technique [O] . Weiwei Wu, Yuangang Zu, Li Wang, 2017

机译：液体抗溶剂沉淀技术的磷酸素纳米粒子的制备表征和抗肿瘤活性评价
7. The ORMULATION OF GLIMEPIRIDE AND ATORVASTATIN CALCIUM NANOPARTICLES BY 1 LIQUID ANTISOLVENT PRECIPITATION METHOD THROUGH DOUBLE STEP COMMINUTION 2 TECHNIQUE AND ITS EVALUATION [O] . 2019

机译：通过双步粉碎2技术通过1液体防溶剂沉淀法通过1液体防溶剂沉淀法进行胶质素和阿托伐他汀钙纳米粒子的晶体化及其评价

Preparation of honokiol nanoparticles by liquid antisolvent precipitation technique characterization pharmacokinetics and evaluation of inhibitory effect on HepG2 cells

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