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首页> 美国卫生研究院文献>International Journal of Nanomedicine >Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment
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Establishment of a biophysical model to optimize endoscopic targeting of magnetic nanoparticles for cancer treatment

机译：建立生物物理模型以优化磁性纳米粒子的内窥镜靶向治疗癌症

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Superparamagnetic iron oxide nanoparticles (SPION) may be used for local tumor treatment by coupling them to a drug and accumulating them locally with magnetic field traps, that is, a combination of permanent magnets and coils. Thereafter, an alternating magnetic field generates heat which may be used to release the thermosensitively bound drug and for hyperthermia. Until today, only superficial tumors can be treated with this method. Our aim was to transfer this method into an endoscopic setting to also reach the majority of tumors located inside the body. To find the ideal endoscopic magnetic field trap, which accumulates the most SPION, we first developed a biophysical model considering anatomical as well as physical conditions. Entities of choice were esophageal and prostate cancer. The magnetic susceptibilities of different porcine and rat tissues were measured with a superconducting quantum interference device. All tissues showed diamagnetic behavior. The evaluation of clinical data (computed tomography scan, endosonography, surgical reports, pathological evaluation) of patients gave insight into the topographical relationship between the tumor and its surroundings. Both were used to establish the biophysical model of the tumors and their surroundings, closely mirroring the clinical situation, in which we could virtually design, place and evaluate different electromagnetic coil configurations to find optimized magnetic field traps for each tumor entity. By simulation, we could show that the efficiency of the magnetic field traps can be enhanced by 38-fold for prostate and 8-fold for esophageal cancer. Therefore, our approach of endoscopic targeting is an improvement of the magnetic drug-targeting setups for SPION tumor therapy as it holds the possibility of reaching tumors inside the body in a minimal-invasive way. Future animal experiments must prove these findings in vivo.
机译：通过将超顺磁性氧化铁纳米粒子（SPION）与药物偶联并通过磁场陷阱（即永磁体和线圈的组合）将其局部累积，可以用于局部肿瘤治疗。此后，交变磁场产生热量，该热量可用于释放热敏结合的药物并用于热疗。直到今天，只能用这种方法治疗浅表肿瘤。我们的目标是将这种方法转移到内窥镜中，以同时到达体内大部分肿瘤。为了找到能够积累最多SPION的理想内窥镜磁场阱，我们首先开发了一种既考虑解剖学又考虑物理条件的生物物理模型。选择的实体是食道癌和前列腺癌。用超导量子干涉仪测量猪和大鼠不同组织的磁化率。所有组织均显示出反磁性行为。对患者的临床数据（计算机断层扫描，超声检查，手术报告，病理学评估）进行评估，可以洞悉肿瘤与其周围环境之间的地形关系。两者均用于建立肿瘤及其周围环境的生物物理模型，密切反映临床情况，在该情况下，我们可以虚拟设计，放置和评估不同的电磁线圈配置，以找到针对每个肿瘤实体的优化磁场阱。通过仿真，我们可以证明，对于前列腺，磁场陷阱的效率可以提高38倍，对于食道癌，效率可以提高8倍。因此，我们的内窥镜靶向方法是对SPION肿瘤治疗的磁性药物靶向设置的一种改进，因为它具有以微创方式到达体内肿瘤的可能性。未来的动物实验必须在体内证明这些发现。

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