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首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus
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Effect of the Polysaccharide Extract from the Edible Mushroom Pleurotus ostreatus against Infectious Bursal Disease Virus

机译：食用菌平菇菌多糖提取物对传染性法氏囊病病毒的影响

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摘要

The polysaccharide-containing extracellular fractions (EFs) of the edible mushroom Pleurotus ostreatus have immunomodulating effects. Being aware of these therapeutic effects of mushroom extracts, we have investigated the synergistic relations between these extracts and BIAVAC and BIAROMVAC vaccines. These vaccines target the stimulation of the immune system in commercial poultry, which are extremely vulnerable in the first days of their lives. By administrating EF with polysaccharides from P. ostreatus to unvaccinated broilers we have noticed slow stimulation of maternal antibodies against infectious bursal disease (IBD) starting from four weeks post hatching. For the broilers vaccinated with BIAVAC and BIAROMVAC vaccines a low to almost complete lack of IBD maternal antibodies has been recorded. By adding 5% and 15% EF in the water intake, as compared to the reaction of the immune system in the previous experiment, the level of IBD antibodies was increased. This has led us to believe that by using this combination of BIAVAC and BIAROMVAC vaccine and EF from P. ostreatus we can obtain good results in stimulating the production of IBD antibodies in the period of the chicken first days of life, which are critical to broilers’ survival. This can be rationalized by the newly proposed reactivity biological activity (ReBiAc) principles by examining the parabolic relationship between EF administration and recorded biological activity.
机译：食用蘑菇平菇侧耳的含多糖的细胞外部分（EFs）具有免疫调节作用。意识到蘑菇提取物的这些治疗作用，我们研究了这些提取物与BIAVAC和BIAROMVAC疫苗之间的协同关系。这些疫苗的目标是刺激商业家禽的免疫系统，这些家禽在出生后的第一天就非常脆弱。通过给未接种疫苗的肉鸡施用EF与来自平菇的多糖，我们注意到从孵化后的四个星期开始，母体针对传染性法氏囊病（IBD）的抗体刺激缓慢。对于用BIAVAC和BIAROMVAC疫苗接种的肉鸡，已记录到几乎完全没有IBD母源抗体。与先前实验中免疫系统的反应相比，通过在饮水中添加5％和15％EF，IBD抗体的水平得以提高。这使我们相信，通过结合使用BIAVAC和BIAROMVAC疫苗以及来自P. ostreatus的EF，我们可以在刺激鸡出生后的第一天获得良好的结果，从而刺激IBD抗体的产生，这对于肉鸡而言至关重要生存。通过检查EF给药与记录的生物活性之间的抛物线关系，可以通过新提议的反应性生物活性（ReBiAc）原理来合理化这一点。

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