• 主题
高级搜索  >
历史搜索 清空历史
首页> 美国卫生研究院文献>International Journal of Molecular Sciences >Association of Genetic Polymorphisms of Renin–Angiotensin–Aldosterone System-Related Genes with Arterio-Venous Fistula Malfunction in Hemodialysis Patients
【2h】

Association of Genetic Polymorphisms of Renin–Angiotensin–Aldosterone System-Related Genes with Arterio-Venous Fistula Malfunction in Hemodialysis Patients

机译：肾素-血管紧张素-醛固酮系统相关基因多态性与血液透析患者动静脉瘘功能障碍的关系

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务，本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文，但由于OA文献来源多样且变更频繁，仍可能出现获取不到、文献不完整或与标题不符等情况，如果获取不到我们将提供退款服务。请知悉。
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Hemodialysis (HD) is the most commonly-used renal replacement therapy for patients with end-stage renal disease worldwide. Arterio-venous fistula (AVF) is the vascular access of choice for HD patients with lowest risk of infection and thrombosis. In addition to environmental factors, genetic factors may also contribute to malfunction of AVF. Previous studies have demonstrated the effect of genotype polymorphisms of angiotensin converting enzyme on vascular access malfunction. We conducted a multicenter, cross-sectional study to evaluate the association between genetic polymorphisms of renin-angiotensin-aldosterone system and AVF malfunction. Totally, 577 patients were enrolled. Their mean age was 60 years old and 53% were male. HD patients with AVF malfunction had longer duration of HD (92.5 ± 68.1 vs. 61.2 ± 51.9 months, p < 0.001), lower prevalence of hypertension (44.8% vs. 55.3%, p = 0.025), right-sided (31.8% vs. 18.4%, p = 0.002) and upper arm AVF (26.6% vs. 9.7%, p < 0.001), and higher mean dynamic venous pressure (DVP) (147.8 ± 28.3 vs. 139.8 ± 30.0, p = 0.021). In subgroup analysis of different genders, location of AVF and DVP remained significant clinical risk factors of AVF malfunction in univariate and multivariate binary logistic regression in female HD patients. Among male HD patients, univariate binary logistic regression analysis revealed that right-side AVF and upper arm location are two important clinical risk factors. In addition, two single nucleotide polymorphisms (SNPs), rs275653 (Odds ratio 1.90, p = 0.038) and rs1492099 (Odds ratio 2.29, p = 0.017) of angiotensin II receptor 1 (AGTR1), were associated with increased risk of AVF malfunction. After adjustment for age and other clinical factors, minor allele-containing genotype polymorphisms (AA and CA) of rs1492099 still remained to be a significant risk factor of AVF malfunction (Odds ratio 3.63, p = 0.005). In conclusion, we demonstrated that rs1492099, a SNP of AGTR1 gene, could be a potential genetic risk factor of AVF malfunction in male HD patients.
机译：血液透析（HD）是全世界终末期肾脏疾病患者最常用的肾脏替代疗法。动静脉瘘（AVF）是感染和血栓形成风险最低的HD患者的首选血管通路。除环境因素外，遗传因素也可能导致AVF的功能障碍。先前的研究已经证明了血管紧张素转化酶的基因型多态性对血管通路功能障碍的影响。我们进行了一项多中心的横断面研究，以评估肾素-血管紧张素-醛固酮系统的遗传多态性与AVF功能障碍之间的关联。共有577名患者入组。他们的平均年龄为60岁，男性为53％。伴有AVF功能障碍的HD患者HD持续时间更长（92.5±68.1 vs. 61.2±51.9个月，p <0.001），高血压患病率较低（44.8％vs. 55.3％，p = 0.025），右侧（31.8％vs 18.4％，p = 0.002）和上臂AVF（26.6％vs. 9.7％，p <0.001），以及更高的平均动态静脉压（DVP）（147.8±28.3 vs. 139.8±30.0，p = 0.021）。在不同性别的亚组分析中，女性HD患者的单因素和多因素二项logistic回归分析中，AVF和DVP的位置仍然是AVF故障的重要临床危险因素。在男性HD患者中，单因素二项Logistic回归分析显示右侧AVF和上臂位置是两个重要的临床危险因素。此外，血管紧张素II受体1（AGTR1）的两个单核苷酸多态性（SNP）rs275653（几率1.90，p = 0.038）和rs1492099（几率2.29，p = 0.017）与AVF故障的风险增加相关。调整年龄和其他临床因素后，rs1492099的较小等位基因等位基因多态性（AA和CA）仍然是AVF机能障碍的重要危险因素（几率3.63，p = 0.005）。总之，我们证明了rs1492099（AGTR1基因的SNP）可能是男性HD患者AVF功能障碍的潜在遗传危险因素。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号