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首页> 美国卫生研究院文献>ACS Omega >Collagen–Hydroxypropyl Methylcellulose Membranesfor Corneal Regeneration
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Collagen–Hydroxypropyl Methylcellulose Membranesfor Corneal Regeneration

机译：胶原蛋白-羟丙基甲基纤维素膜用于角膜再生

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摘要

To improve intraocular transparency of collagen matrices, hydroxypropyl methylcellulose (HPMC) was introduced for the first time into cross-linked collagen to form collagen–HPMC composite membranes. Light transmittance and refractive indices of the membranes are enhanced by incorporation of HPMC in comparison to the control of cross-linked collagen membranes. Maximum light transmittance of the collagen–HPMC membrane was up to 92%. In addition, their permeability of nutrients such as glucose, tryptophan, and NaCl was superior or comparable to that of human corneas. In vitro results demonstrated that the collagen–HPMC membrane supported adhesion and proliferation of human corneal epithelial cells (HCECs), showing good cytocompatibility to HCECs. The corneas maintained a smooth surface and clear stroma postoperatively after 7 months of implantation of collagen–HPMC membranes into the corneas of rabbits. The good intraocular biocompatibility was verified by maintaining a high optical clarity for over 6 months after transplantation. Hematoxylin and eosin staining results showed the growth of stromal keratocytesinto the collagen–HPMC implants, indicating the ability ofthe collagen–HPMC membrane to induce corneal cell regeneration.Taken together, the collagen–HPMC membrane might be a promisingcandidate for use in corneal repair and regeneration.
机译：为了提高胶原蛋白基质的眼内透明度，首次将羟丙基甲基纤维素（HPMC）引入交联的胶原蛋白中以形成胶原蛋白-HPMC复合膜。与对照的交联胶原膜相比，通过掺入HPMC可以提高膜的透光率和折射率。胶原蛋白-HPMC膜的最大透光率高达92％。另外，它们对诸如葡萄糖，色氨酸和NaCl等营养物的渗透性优于或可与人角膜相媲美。体外结果表明，胶原蛋白-HPMC膜支持人角膜上皮细胞（HCEC）的粘附和增殖，显示出与HCEC良好的细胞相容性。胶原-HPMC膜植入兔角膜7个月后，角膜表面保持光滑，基质清晰。通过在移植后6个月内保持较高的光学透明度来验证良好的眼内生物相容性。苏木精和曙红染色结果显示间质角膜细胞生长进入胶原蛋白-HPMC植入物，表明胶原蛋白-HPMC膜可诱导角膜细胞再生。综上所述，胶原蛋白-HPMC膜可能很有希望用于角膜修复和再生的候选人。

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