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首页> 美国卫生研究院文献>International Journal of Clinical and Experimental Pathology >A Morphometric Study of Antral G-Cell Density in a Sample of Adult General Population: Comparison of Three Different Methods and Correlation with Patient Demography Helicobacter pylori Infection Histomorphology and Circulating Gastrin Levels
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A Morphometric Study of Antral G-Cell Density in a Sample of Adult General Population: Comparison of Three Different Methods and Correlation with Patient Demography Helicobacter pylori Infection Histomorphology and Circulating Gastrin Levels

机译：成人普通人群中肛门G细胞密度的形态计量学研究：三种不同方法的比较以及与患者人口统计学幽门螺杆菌感染组织形态学和循环胃泌素水平的相关性

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Helicobacter pylori infection has been linked to hypergastrinemia and either decreased or normal G-cell content in the antral mucosa. To clarify this controversial issue, we quantitatively determined antral G-cell content on the same biopsy specimens with three different methods and examined whether these methods are intercorrelated and the relation of these methods to plasma gastrin concentrations, demography, the occurrence of H. pylori infection and chronic gastritis. Gastric antral mucosal biopsy sections from 273 adults (188 with and 85 without H pylori infection) from a general population sample were examined immunohistochemically for G-cells using cell counting, stereology (point counting) and computerized image analysis. Gastritis was scored according to the updated Sydney system. Basal plasma gastrin concentrations were measured by radioimmunoassay. The three methods for G-cell quantification were poorly correlated and the results showed no correlation with basal plasma gastrin concentrations. The antral G-cell density and scores for H. pylori colonization were positively related to age. Neither the scores for chronic inflammation, nor the scores for inflammatory activity, atrophy or intestinal metaplasia were consistently related to the antral G-cell content. In conclusion, the results of three techniques for G-cell quantification in the gastric antral mucosa were poorly intercorrelated and none of the methods correlated with plasma gastrin concentrations. Age and scores for H pylori colonization seem to be determinants of the G-cell density. That common morphometric techniques correlate poorly is of utmost importance to bear in mind when quantitative morphological studies are planned, compared or interpreted.
机译：幽门螺杆菌感染与胃泌素过多症有关，并与胃窦粘膜中G细胞含量降低或正常有关。为了澄清这个有争议的问题，我们使用三种不同的方法定量测定了同一活检标本中的肛门G细胞含量，并检查了这些方法是否相互关联以及这些方法与血浆胃泌素浓度，人口统计学和幽门螺杆菌感染的关系。和慢性胃炎。使用细胞计数，体视学（点计数）和计算机图像分析，对来自一般人群样本的273名成人（188例幽门螺杆菌感染和85例无H幽门螺杆菌感染）的胃窦黏膜活检切片进行了免疫组织化学检查，以检查G细胞。胃炎是根据最新的悉尼系统评分的。通过放射免疫测定法测定基础血浆胃泌素浓度。三种G细胞定量方法的相关性较弱，结果显示与基础血浆胃泌素浓度无相关性。胃窦G细胞密度和幽门螺杆菌定殖评分与年龄呈正相关。慢性炎症评分，炎症活动，萎缩或肠化生评分均与胃窦G细胞含量无关。总之，胃窦粘膜中G细胞定量的三种技术的相关性很差，并且没有一种方法与血浆胃泌素浓度相关。幽门螺杆菌定植的年龄和分数似乎是G细胞密度的决定因素。当计划，比较或解释定量形态学研究时，要牢记最常见的形态学技术关联性很差。

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