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Immunotoxicological impact of occupational and environmental nanoparticles exposure: The influence of physical chemical and combined characteristics of the particles

机译:职业性和环境性纳米颗粒暴露的免疫毒理学影响:颗粒的物理化学和组合特征的影响

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摘要

While nanotechnology is growing exponentially, the knowledge of the impact of nanoparticles (NPs) on public health and the environment is limited so far. Current nanomaterial research is focused on the applications of nanotechnology, whereas there is little information on exposure assessment and risk characterization associated with NPs. Therefore, it is essential that the factors influencing NPs associated hazards be studied. This review seeks to survey and evaluate the current literature in order to better understand the impact of both airborne and engineered NPs exposure, the mechanisms at the cellular level, and the factors influencing their immunotoxicity. In fact, NPs do have immunotoxicological significance, as immune cells in the bloodstream and tissues do act to eliminate or interact with NPs.Proper characterization of the NPs as well as understanding the processes occurring on the NPs surface when in contact with biological systems is crucial to predict or exclude toxicological effects.
机译:尽管纳米技术呈指数级增长,但到目前为止,有关纳米颗粒(NP)对公共健康和环境影响的知识仍然有限。当前的纳米材料研究集中在纳米技术的应用上,而关于NPs的暴露评估和风险表征的信息很少。因此,必须研究影响NPs相关危害的因素。这篇综述旨在调查和评估当前的文献,以便更好地了解机载和工程NPs暴露的影响,细胞水平的机制以及影响其免疫毒性的因素。实际上,NPs确实具有免疫毒理学意义,因为血液和组织中的免疫细胞确实起着消除或与NPs相互作用的作用.NPs的正确表征以及与生物系统接触时了解NPs表面发生的过程至关重要。预测或排除毒理作用。

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