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首页> 美国卫生研究院文献>International Journal of Endocrinology >Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor
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Comparison of Lipoprotein-Associated Phospholipase A2 and High Sensitive C-Reactive Protein as Determinants of Metabolic Syndrome in Subjects without Coronary Heart Disease: In Search of the Best Predictor

机译：脂蛋白相关的磷脂酶A2和高敏C反应蛋白作为无冠心病受试者代谢综合征的决定因素的比较：寻求最佳预测指标

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High sensitivity C-reactive protein (hsCRP) is a marker of metabolic syndrome (MS) and cardiovascular (CV) disease. Lipoprotein-associated phospholipase A2 (Lp-PLA2) also predicts CV disease. There are no reports comparing these markers as predictors of MS. Methods. Cross-sectional study comparing Lp-PLA2 and hsCRP as predictors of MS in asymptomatic subjects was carried out; 152 subjects without known atherosclerosis participated. Data were collected on demographics, cardiovascular risk factors, anthropometric and biochemical measurements, and hsCRP and Lp-PLA2 activity levels. A logistic regression analysis was performed with each biomarker and receiver operating characteristic (ROC) curves were constructed for MS. Results. Mean age was 46 ± 11 years, and 38% of the subjects had MS. Mean Lp-PLA2 activity was 185 ± 48 nmol/mL/min, and mean hsCRP was 2.1 ± 2.2 mg/L. Subjects with MS had significantly higher levels of Lp-PLA2 (P = 0.03) and hsCRP (P < 0.0001) than those without MS. ROC curves showed that both markers predicted MS. Conclusion. Lp-PLA2 and hsCRP are elevated in subjects with MS. Both biomarkers were independent and significant predictors for MS, emphasizing the role of inflammation in MS. Further research is necessary to determine if inflammation predicts a higher risk for CV events in MS subjects.
机译：高敏C反应蛋白（hsCRP）是代谢综合征（MS）和心血管（CV）疾病的标志。脂蛋白相关的磷脂酶A2（Lp-PLA2）也可预测心血管疾病。没有报道将这些标志物作为MS的预测指标进行比较。方法。进行了横断面研究，比较了Lp-PLA2和hsCRP作为无症状受试者MS的预测指标。 152名无已知动脉粥样硬化的受试者参加。收集有关人口统计学，心血管危险因素，人体测量学和生化测量以及hsCRP和Lp-PLA2活性水平的数据。对每个生物标记物进行了逻辑回归分析，并为MS构建了受体工作特征（ROC）曲线。结果。平均年龄为46±11岁，38％的受试者患有MS。 Lp-PLA2平均活性为185±48 nmol / mL / min，平均hsCRP为2.1±2.2 mg / L。患有MS的受试者的Lp-PLA2（p = 0.03）和hsCRP（P <0.0001）的水平明显高于未患有MS的受试者。 ROC曲线显示这两个标记均预测MS。结论。 MS患者中Lp-PLA2和hsCRP升高。两种生物标志物都是MS的独立且重要的预测指标，强调了炎症在MS中的作用。需要进一步的研究来确定炎症是否预测MS受试者发生CV事件的风险更高。

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