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Ethynilestradiol 20 mcg plus Levonorgestrel 100 mcg: Clinical Pharmacology

机译:乙炔雌二醇20 mcg加左炔诺孕酮100 mcg:临床药理学

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摘要

Estroprogestins (EPs) are combinations of estrogen and progestin with several actions on women's health. The different pharmacological composition of EPs is responsible for different clinical effects. One of the most used low-dose EP associations is ethinylestradiol 20 mcg plus levonorgestrel 100 mcg in monophasic regimen (EE20/LNG100). This review summarizes clinical pharmacology, cycle control, and effects on lipid and glucose metabolism, coagulation, body weight/body composition, acne, and sexuality of EE20/LNG100. Overall, EE20/LNG100 combination is safe and well tolerated, and in several studies the incidence of adverse events in the treated group was comparable to that of the placebo group. Cycle control was effective and body weight/body composition did not vary among treated and untreated groups in most studies. The EE20/LNG100 combination shows mild or no effect on lipid and glucose metabolism. Lastly, EE20/LNG100 is associated with a low risk of venous thromboembolism (VTE). In conclusion, in the process of decision making for the individualization of EPs choice, EE20/LNG100 should be considered for its favorable clinical profile.
机译:雌激素(EPs)是雌激素和孕激素的组合,对妇女的健康有多种作用。 EP的不同药理成分负责不同的临床效果。最常用的低剂量EP协会之一是单相疗法(EE20 / LNG100)中的炔雌醇20 mcg加左炔诺孕酮100 mcg。这篇综述总结了EE20 / LNG100的临床药理学,周期控制以及对脂质和葡萄糖代谢,凝血,体重/身体组成,粉刺和性行为的影响。总体而言,EE20 / LNG100组合是安全且耐受性良好的,在一些研究中,治疗组的不良事件发生率与安慰剂组相当。在大多数研究中,治疗和未治疗组之间的周期控制都是有效的,体重/身体组成没有变化。 EE20 / LNG100组合对脂质和葡萄糖代谢显示轻微或无影响。最后,EE20 / LNG100与静脉血栓栓塞(VTE)的低风险相关。总之,在决定EP个体化的决策过程中,应考虑EE20 / LNG100的临床特征。

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