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首页> 美国卫生研究院文献>International Journal of Chronic Obstructive Pulmonary Disease >Impact and factors associated with nighttime and early morning symptoms among patients with chronic obstructive pulmonary disease
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Impact and factors associated with nighttime and early morning symptoms among patients with chronic obstructive pulmonary disease

机译：慢性阻塞性肺疾病患者夜间和清晨症状的影响及相关因素

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Patients with chronic obstructive pulmonary disease (COPD) exhibit poor sleep quality and consider morning as the worst time of day for their symptoms. While work has been done to characterize nighttime (NT) and early morning (EM) symptoms in various populations, the impact and factors associated with NT/EM symptoms among patients with COPD in the United States is not well understood. Commercially insured patients aged ≥40 years with one or more medical claim for COPD and one or more pharmacy claim for COPD maintenance medication were identified from the HealthCore Integrated Research Database between September 1, 2010 and August 31, 2011. Consenting respondents were asked whether they had COPD symptoms on at least three nights or at least three mornings during the past week. Respondents were then either assigned to one of three symptom groups to complete the survey or excluded if their predefined group quota limit had been met. Survey completers completed the survey with questions about COPD symptoms and other commonly used patient-reported outcome measures. Respondents with NT/EM symptoms were asked about the frequency, severity, and impact of the symptoms on sleep, morning activities, and anxiety levels. Among respondents with symptoms, 73.1% of respondents with NT symptoms (N=376) and 83% of respondents with EM symptoms (N=506) experienced at least three distinct types of symptoms over the past week, with cough being the most frequently reported symptom. Approximately half of respondents with NT or EM symptoms perceived their symptoms as moderate to very severe, with a majority reporting their symptoms affected their NT sleep and morning activities, and more than half felt anxious due to their symptoms. Multinomial logistic regression showed COPD patients with both or either NT/EM symptoms were associated with poorer health status compared to those without. Improved disease management may reduce NT/EM symptoms and improve health status in patients with COPD.
机译：患有慢性阻塞性肺疾病（COPD）的患者睡眠质量较差，因此将早晨视为其症状的最差时间。尽管已经进行了表征各种人群的夜间（NT）和清晨（EM）症状的工作，但在美国COPD患者中与NT / EM症状相关的影响和因素尚不十分清楚。在2010年9月1日至2011年8月31日期间，从HealthCore综合研究数据库中识别出年龄≥40岁且有一项或多项COPD医疗索赔以及一项或多项COPD维持药物治疗的商业保险患者。询问是否同意他们的回答在过去一周中，至少有三晚或至少三天有COPD症状。然后，将受访者分配到三个症状组之一以完成调查，或者如果满足其预定义的组配额限制，则将其排除。调查完成者对COPD症状和其他常用的患者报告的结局指标提出了疑问。询问具有NT / EM症状的受访者有关症状的频率，严重性以及其对睡眠，早晨活动和焦虑程度的影响。在有症状的受访者中，NT症状（N = 376）的受访者中有73.1％，在EM症状（N = 506）的受访者中有83％的人在过去一周中经历了至少三种不同类型的症状，其中咳嗽是最常见的症状。大约有NT或EM症状的受访者认为他们的症状为中度到非常严重，大多数报告称他们的症状影响了他们的NT睡眠和早晨活动，而超过一半的人由于症状而感到焦虑。多项logistic回归分析显示，与没有或没有NT / EM症状的COPD患者相比，NTPD和EM症状均较差。改善疾病管理可能会减轻COPD患者的NT / EM症状并改善健康状况。

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